5-乙基-4-羟基-6-甲基-2H-吡喃-2-酮 | 83436-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 中文名称: 5-乙基-4-羟基-6-甲基-2H-吡喃-2-酮
• 英文名称: 5-Ethyl-4-hydroxy-6-methyl-2H-pyran-2-on
• 英文别名: 5-Ethyl-4-hydroxy-6-methyl-2-pyrone；5-ethyl-4-hydroxy-6-methylpyran-2-one
• CAS: 83436-27-5
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: WLKDPQMZVYOOPI-UHFFFAOYSA-N

物化性质

• 沸点：
  257.4±40.0 °C(Predicted)
• 密度：
  1.194±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-phenylprop-2-ynyl carbonate 、 5-乙基-4-羟基-6-甲基-2H-吡喃-2-酮 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 1,1'-双(二苯基膦)二茂铁 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以78%的产率得到7-ethyl-6-methyl-3-methylene-2-phenyl-2H-furo[3,2-c]pyran-4(3H)-one
  参考文献：
  名称：

  Regiocontrolled Construction of Furo[3,2-c]pyran-4-one Derivatives by Palladium-Catalyzed Cyclization of Propargylic Carbonates with 4-Hydroxy-2-pyrones

  摘要：

  The reaction of propargylic carbonates with 4-hydroxy-2-pyrones in the presence of a palladium catalyst is described. By the choice of the reaction temperature, two types of the substituted furo[3,2-c]pyran-4-one derivatives were regioselectively synthesized, respectively.

  DOI：

  10.1021/jo3027092
• 作为产物：
  描述：

  丙二酰氯 、 Z-2-Methoxypent-2-en 以11%的产率得到
  参考文献：
  名称：

  EFFENBERGER, F.;SCHOENWAELDER, K. -H.;STEZOWSKI, J. J., ANGEW. CHEM., 1982, 94, N 11, 863-864

  摘要：

  DOI：

文献信息

• Synthesis of pyrone-annulated 2-oxabicyclo[3.3.1]nonanes by palladium-catalyzed cyclization of 4-hydroxy-2-pyrones with allylic bisacetates
  作者：Masahiro Yoshida、Miki Shibata、Saaya Mukae、Kouki Kinoshita、Kenji Matsumoto、Tsukasa Hirokane

  DOI：10.1016/j.tetlet.2019.151262

  日期：2019.12

  Cyclization of 4-hydroxy-2-pyrones with allylic bisacetates by a palladium catalyst is described. Pyrone-annulated 2-oxabicyclo[3.3.1]nonane derivatives were regioselectively produced from the reaction of 4-hydroxy-2-pyrones with 1,4-diacetoxy-2-cyclohexene at high temperature. The reaction would proceed via a migration of the π-allylpalladium intermediate.

  描述了通过钯催化剂用烯丙基双乙酸酯对4-羟基-2-吡喃酮的环化。吡咯环化的2-氧杂双环[3.3.1]壬烷衍生物是由4-羟基-2-吡喃酮与1,4-二乙酰氧基-2-环己烯在高温下反应区域选择性生成的。该反应将通过π-烯丙基铝中间体的迁移而进行。
• Ketone derivatives and medical application thereof
  申请人：Toray Industries, Inc.

  公开号：US06215016B1

  公开（公告）日：2001-04-10

  The present invention relates to ketone derivatives represented by the following formula and medical agents containing the ketone derivatives or pharmacologically acceptable salts thereof as an active ingredient, and in particular, relates to a hematopoietic agent; it is shown that the present invention increases blood cells, such as platelets, white blood cells, and red blood cells, and is effective in preventing and treating cytopenia caused by cancer chemotherapy, radiation therapy, and the like.

  本发明涉及以下式表示的酮衍生物及含有该酮衍生物或其药学上可接受的盐为活性成分的医药制剂，特别是涉及一种造血剂；本发明表明该制剂可提高血小板、白细胞和红细胞等血细胞数量，对于预防和治疗由癌症化疗、放疗等引起的细胞减少症具有良好的疗效。
• KETONE DERIVATIVES AND MEDICINAL USE THEREOF
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0841063A1

  公开（公告）日：1998-05-13

  The present invention relates to ketone derivatives represented by the following formula and medical agents cotaining the ketone derivatives or pharmacologically acceptable salts thereof as an active ingredient, and in particular, relates to a hematopoietic agent; it is shown that the present invention increases blood cells, such as platelets, white blood cells, and red blood cells, and is effective in preventing and treating cytopenia caused by cancer chemotherapy, radiation therapy, and the like.

  本发明涉及下式所代表的酮衍生物和以酮衍生物或其药理学上可接受的盐作为活性成分的医用制剂，特别是涉及一种造血制剂；本发明可增加血小板、白细胞和红细胞等血细胞，对预防和治疗癌症化疗、放疗等引起的细胞减少症有效。
• Effenberger, Franz; Schoenwaelder, Karl-Heinz, Chemische Berichte, 1984, vol. 117, # 11, p. 3270 - 3279
  作者：Effenberger, Franz、Schoenwaelder, Karl-Heinz

  DOI：——

  日期：——
• Effenberger, Franz; Schoenwaelder, Karl-Heinz; Stezowski, John J., Angewandte Chemie, 1982, vol. 94, # 11, p. 863 - 864
  作者：Effenberger, Franz、Schoenwaelder, Karl-Heinz、Stezowski, John J.

  DOI：——

  日期：——