[6aR,9S]-9-(4-Benzhydryl-piperazin-1-ylmethyl)-4,7-dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline | 288388-80-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [6aR,9S]-9-(4-Benzhydryl-piperazin-1-ylmethyl)-4,7-dimethyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline
• 英文别名: (6aR,9S)-9-[(4-benzhydrylpiperazin-1-yl)methyl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline
• CAS: 288388-80-7
• 化学式: C₃₄H₃₈N₄
• 分子量: 502.703
• InChiKey: JOCPUFWCYVVITJ-NLGDKJDOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  14.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Piperidine and piperazine derivatives as inhibitors of the abeta fibril formation
  申请人：——

  公开号：US20020002170A1

  公开（公告）日：2002-01-03

  The invention provides a compound of formula I 1 wherein R, X, Y 1 and Y 2 are as defined in the description, and a process for preparing them. The compounds of formula I are useful as pharmaceuticals.

  这项发明提供了I1式化合物，其中R、X、Y1和Y2如描述中所定义，并提供了制备它们的方法。I式化合物在制药方面有用。
• PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION
  申请人：Novartis AG

  公开号：EP1150971A1

  公开（公告）日：2001-11-07
• [EN] PIPERIDINE AND PIPERAZINE DERIVATIVES AS INHIBITORS OF THE ABETA FIBRIL FORMATION<br/>[FR] DERIVES DE LA PIPERIDINE AND PIPERAZINE INHIBITEURS DE LA FORMATION DES FIBRILLES A beta
  申请人：NOVARTIS AG

  公开号：WO2000047571A1

  公开（公告）日：2000-08-17

  A compound of formula (I) wherein X is (II) or (III) wherein R' is a group (a), R is a group (e) or (f) wherein n is 0 to 3. In particular the agents of the invention inhibit the formation of β-amyloid (Aβ) peptide into neurotoxic fibrils, thereby acting to prevent or slow down the accumulation of amyloid protein deposits in the brain.