| 1152421-44-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1152421-44-7
• 化学式: C₄₁H₅₄N₄O₂₀
• 分子量: 922.895
• InChiKey: HTZFLDLCXGCXSU-ZRJLBWFBSA-N

物化性质

• 沸点：
  1329.1±65.0 °C(predicted)
• 密度：
  1.60±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.78
• 重原子数：
  65.0
• 可旋转键数：
  16.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  370.92
• 氢给体数：
  13.0
• 氢受体数：
  19.0

反应信息

• 作为产物：
  描述：

  2-methyl-4,5-dihydro-[4-O-(β-D-glucopyranosyl)-1,2-dideoxy-α-D-glucopyranoso][2,1-d]-1,3-oxazole 、 Fmoc-Asn(GlcNAc)-OH 在 endo-β-N-acetylglucosaminidase 作用下， 以 phosphate buffer 为溶剂， 反应 48.0h， 生成 Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)b-GlcNAc 、 、 Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)b-GlcNAc 、 、 Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)GlcNAc(b1-4)Glc(b1-4)b-GlcNAc 、
  参考文献：
  名称：

  Endo-β-N-acetylglucosaminidase-catalyzed polymerization of β-Glcp-(1→4)-GlcpNAc oxazoline: a revisit to enzymatic transglycosylation

  摘要：

  An alternative synthesis of beta-Glcp-(1 -> 4)-GlcpNAc oxazoline is described, and its enzymatic reaction with the endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae (Endo-A) was re-investigated. Under normal transglycosylation conditions with a catalytic amount of enzyme, Enclo-A showed only marginal activity for transglycosylation with the disaccharide oxazoline, consistent with our previous observations. However, when used in a relatively large quantity, Endo-A could promote the transglycosylation of the disaccharide oxazoline to a GlcpNAc-Asn acceptor. In addition to the initial transglycosylation product, a series of large oligosaccharides were also formed due to the tandem transglycosylation to the terminal glucose residues in the intermediate products. In the absence of an external acceptor, Enclo-A could polymerize the disaccharide oxazoline to form oligo- and polysaccharides having the -4-beta-(Glcp-(1 -> 4)-beta-GlcpNAc)-1-repeating units. This is the first example of an endo-beta-N-acetylglucosaminidase-promoted polymerization of activated oligosaccharide substrates. This enzymatic polymerization may find useful applications for the synthesis of novel artificial polysaccharides. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2009.01.016