phosphoric acid bis-(4-iodo-benzyl ester) | 64976-63-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phosphoric acid bis-(4-iodo-benzyl ester)
• 英文别名: Phosphorsaeure-bis-(4-jod-benzylester)；Benzenemethanol, 4-iodo-, hydrogen phosphate；bis[(4-iodophenyl)methyl] hydrogen phosphate
• CAS: 64976-63-2
• 化学式: C₁₄H₁₃I₂O₄P
• 分子量: 530.038
• InChiKey: KXJWAKJAVNOKQA-UHFFFAOYSA-N

物化性质

• 熔点：
  178 °C
• 沸点：
  521.7±60.0 °C(Predicted)
• 密度：
  2.027±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.73
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  phosphoric acid bis-(4-iodo-benzyl ester) 在 氯仿 、 五氯化磷 作用下， 生成 chlorophosphoric acid bis-(4-iodo-benzyl ester)
  参考文献：
  名称：

  Dealkylation and Debenzylation of Triesters of Phosphoric Acid. Phosphorylation of Hydroxy and Amino Compounds

  摘要：

  DOI：

  10.1021/ja01625a045
• 作为产物：
  描述：

  phosphoric acid tris-(4-iodo-benzyl ester) 在 丙酮 、 sodium iodide 作用下， 生成 4-iodobenzyl iodide 、 phosphoric acid bis-(4-iodo-benzyl ester)
  参考文献：
  名称：

  Dealkylation and Debenzylation of Triesters of Phosphoric Acid. Phosphorylation of Hydroxy and Amino Compounds

  摘要：

  DOI：

  10.1021/ja01625a045

文献信息

• Mood Disorders During Pregnancy and Lactation: Defining Issues of Exposure and Treatment
  作者：Zachary N. Stowe、Kelley Calhoun、Clayton Ramsey、Noha Sadek、Jeffrey Newport

  DOI：10.1017/s1092852900007914

  日期：2001.2

  Epidemiologic studies have consistently demonstrated a greater incidence of depressive disorders and anxiety among women. Many women experience these conditions during the reproductive years. The dramatic expanse of literature focusing on the use of medications often has failed to pay homage to the potential impact of the disorders. When considering the extant human and laboratory data on mental illness and stress during pregnancy and the postpartum period, it is evident that some degree of exposure (be it treatment or illness) always occurs. The primary goal of the risk-benefit assessment for the treatment of mental illness during these periods is to assist patients and their families in choosing the path of potential exposure that possesses the least risk for them. Once this decision is made, the goal is to limit the number of exposures for the fetus/neonate.

  摘要流行病学研究一致表明，女性抑郁症和焦虑症的发病率较高。许多女性在生育期都会出现这些症状。大量文献关注的是药物的使用，却往往忽视了这些疾病的潜在影响。从人类和实验室关于孕期和产后精神疾病和压力的现有数据来看，显然总会有一定程度的接触（无论是治疗还是疾病）。对这些时期的精神疾病治疗进行风险效益评估的主要目的，是帮助患者及其家属选择对他们来说风险最小的潜在暴露途径。一旦做出这一决定，目标就是限制胎儿/新生儿接触的次数。