1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-bromouracil | 121749-97-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-bromouracil
• 英文别名: 5-bromo-1-[2-[tert-butyl(dimethyl)silyl]oxyethoxymethyl]pyrimidine-2,4-dione
• CAS: 121749-97-1
• 化学式: C₁₃H₂₃BrN₂O₄Si
• 分子量: 379.326
• InChiKey: GNYMMMQSDJSRPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  73.32
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-bromouracil 在 碘 、 lithium diisopropyl amide 作用下， 生成 5-Bromo-1-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxymethyl]-6-iodo-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  一种新的特定抗HIV-1药物的铅：1-[（（2-羟基乙氧基）甲基] -6-（苯硫基）胸腺嘧啶。

  摘要：

  DOI：

  10.1021/jm00132a002
• 作为产物：
  描述：

  1-(2-羟基乙氧基)甲基-5-溴尿嘧啶 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以83%的产率得到1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-bromouracil
  参考文献：
  名称：

  Activity of acyclic 6-(phenylselenenyl)pyrimidine nucleosides against human immunodeficiency viruses in primary lymphocytes

  摘要：

  Several 6-phenylselenenyl-substituted acyclouridine derivatives were prepared for evaluation as antiviral agents. Lithiation of the tert-butyldimethylsilyl-protected acyclonucleosides 4a-f with lithium diisopropylamide at -78-degrees-C, followed by reaction with diphenyl diselenide as an electrophile, and subsequent removal of the protecting group with tetra n-butylammonium fluoride gave 1-[(2-hydroxyethoxy)methyl]-6-(phenylselenenyl)uracils 6a-f in 50-70% overall yield. The potency and spectrum of activity of compounds 6a-f against HIV-1 in vitro was similar to HEPT (1), a related 6-phenylthio acyclonucleoside. However, whereas HEPT inhibited HIV-1 reverse transcriptase, the selenium-containing derivatives were ineffective, suggesting a different mechanism of action. Of significance was the finding that the 6-phenylselenenyl acyclonucleosides inhibited also HIV-2 in primary human lymphocytes.

  DOI：

  10.1021/jm00115a022

文献信息

• BUNDGAARD, HANS;FALCH, ERIK;JENSEN, EJVIND, J. MED. CHEM., 32,(1989) N2, C. 2507-2509
  作者：BUNDGAARD, HANS、FALCH, ERIK、JENSEN, EJVIND

  DOI：——

  日期：——