丙炔基-一聚乙二醇-羧酸 | 1859379-85-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 丙炔基-一聚乙二醇-羧酸
• 中文别名: 丙炔基-PEG2-丙酸；丙炔-二乙二醇-羧酸；丙炔-单乙二醇-丙酸叔丁酯；丙炔-单乙二醇-丙酸
• 英文名称: 3-(2-(prop-2-yn-1-yloxy)ethoxy)propanoic acid
• 英文别名: Propargyl-PEG2-acid；3-(2-prop-2-ynoxyethoxy)propanoic acid
• CAS: 1859379-85-3
• 化学式: C₈H₁₂O₄
• 分子量: 172.181
• InChiKey: NNWHATPXNWOQKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• WGK Germany：
  3
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  丙炔基-一聚乙二醇-羧酸 在 吡啶 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 3.0h， 生成 Pomalidomide-CO-PEG2-propargyl
  参考文献：
  名称：

  Development of Biocompatible Cu(I)‐Microdevices for Bioorthogonal Uncaging and Click Reactions

  摘要：

  Transition‐metal‐catalyzed bioorthogonal reactions emerged a decade ago as a novel strategy to implement spatiotemporal control over enzymatic functions and pharmacological interventions. The use of this methodology in experimental therapy is driven by the ambition of improving the tolerability and PK properties of clinically‐used therapeutic agents. The preclinical potential of bioorthogonal catalysis has been validated in vitro and in vivo with the in situ generation of a broad range of drugs, including cytotoxic agents, anti‐inflammatory drugs and anxiolytics. In this article, we report our investigations towards the preparation of solid‐supported Cu(I)‐microdevices and their application in bioorthogonal uncaging and click reactions. A range of ligand‐functionalized polymeric devices and off‐on Cu(I)‐sensitive sensors were developed and tested under conditions compatible with life. Last, we present a preliminary exploration of their use for the synthesis of PROTACs through CuAAC assembly of two heterofunctional mating units.

  DOI：

  10.1002/chem.202400611

文献信息

• NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
  申请人：BOUCHARD Hervé

  公开号：US20120225089A1

  公开（公告）日：2012-09-06

  Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided.

  本发明提供了隐藻素偶联物及其包含它们的组合物。还提供了制备和使用此类化合物的方法。
• [EN] ANTIBODY DRUG CONJUGATES USING MATES TECHNOLOGY FOR DELIVERING CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS ANTICORPS-MÉDICAMENT UTILISANT UNE TECHNOLOGIE DE COUPLAGE POUR ADMINISTRER DES AGENTS CYTOTOXIQUES
  申请人：BIOHAVEN THERAPEUTICS LTD

  公开号：WO2022246086A1

  公开（公告）日：2022-11-24

  Among other things, the present disclosure provides technologies for site-directed conjugation of various moieties of interest to target agents. In some embodiments, the present disclosure utilizes target binding moieties to provide high conjugation efficiency and selectivity. In some embodiments, provided technologies are useful for preparing antibody conjugates.

  除其他事项外，本公开提供了用于将各种感兴趣的物质定向结合到目标试剂上的技术。在某些实施例中，本公开利用目标结合物质提供高结合效率和选择性。在某些实施例中，提供的技术对于制备抗体结合物很有用。
• [EN] PROTEIN STABILIZING COMPOUNDS CONTAINING USP7 LIGANDS<br/>[FR] COMPOSÉS DE STABILISATION DE PROTÉINE CONTENANT DES LIGANDS D'USP7
  申请人：STABLIX INC

  公开号：WO2022272133A3

  公开（公告）日：2023-02-09
• [EN] TECHNOLOGIES FOR PREVENTING OR TREATING INFECTIONS<br/>[FR] TECHNOLOGIES DE PRÉVENTION OU DE TRAITEMENT D'INFECTIONS
  申请人：BIOHAVEN THERAPEUTICS LTD

  公开号：WO2022170155A3

  公开（公告）日：2022-09-29
• AZLACTONE FUNCTIONALIZED SUBSTRATES FOR CONJUGATION OF BIOMOLECULES
  申请人：Robert Bosch GmbH

  公开号：US20170342211A1

  公开（公告）日：2017-11-30

  A bifunctional polymer is functionalized at one end with an azlactone end group to conjugate biomolecules of interest, and is functionalized at another end with an azide anchor group to attach the polymer to a substrate. Methods of making the bifunctional polymer are also provided. A coated substrate includes the bifunctionalized polymers on the surface of a substrate. Methods of making the coated substrate are also provided. A microarray includes a plurality of discrete regions, each region including the coated substrate.