5-butyl-2,3-dihydro-1H-indole | 67932-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-butyl-2,3-dihydro-1H-indole
• 英文别名: BBV-020274；5-Butylindoline
• CAS: 67932-67-6
• 化学式: C₁₂H₁₇N
• 分子量: 175.274
• InChiKey: ZIGXCARKYMFZKU-UHFFFAOYSA-N

物化性质

• 沸点：
  287.0±25.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] MITOCHONDRIAL COMPLEX I INHIBITORS AND METHODS OF USE<br/>[FR] INHIBITEURS DU COMPLEXE MITOCHONDRIAL I ET MÉTHODES D'UTILISATION
  申请人：SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST

  公开号：WO2021050547A1

  公开（公告）日：2021-03-18

  Disclosed herein are methods of using mitochondrial complex I inhibitors in the treatment of a disease or condition that would benefit from the inhibition of mitochondrial respiration. Also described herein are methods of treating a disease or condition such as prostate cancer and breast cancer by administering a mitochondrial complex I inhibitor in combination with a second therapeutic agent.

  本文披露了使用线粒体复合物I抑制剂治疗需要抑制线粒体呼吸的疾病或状况的方法。本文还描述了通过联合使用线粒体复合物I抑制剂和第二治疗剂来治疗前列腺癌和乳腺癌等疾病或状况的方法。
• Palladium-catalyzed carbon-carbon bond forming reactions
  申请人：Liu R. David

  公开号：US20070066851A1

  公开（公告）日：2007-03-22

  A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium may be used in the reaction if an oxidant is present. The reactions is also compatible with a variety of organic solvent as well as aqueous solution. Both intermolecular and intramolecular reactions have been demonstrated. This novel carbon-carbon bond forming reaction is particularly useful in the synthesis of macrocycles. Kits, reagents, catalysts, solvents, oxidants, salts, acids, instructions, and other materials useful in the practice of the inventive reaction are also provided.

  一项新型的钯介导的碳-碳键形成反应已经通过DNA模板化学发现。这种创新的反应涉及到钯介导的末端炔与烯烃的偶联反应，形成烯酮。如果存在氧化剂，则可以在反应中使用少量的催化剂钯。该反应还与多种有机溶剂以及水溶液兼容。已经证明了分子间和分子内反应。这种新型的碳-碳键形成反应在大环合成中特别有用。同时还提供了工具包、试剂、催化剂、溶剂、氧化剂、盐、酸、说明书和其他在实践中有用的材料。
• US4159271A
  申请人：——

  公开号：US4159271A

  公开（公告）日：1979-06-26