2,6-bis((2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)methyl)pyridine | 1210043-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-bis((2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)methyl)pyridine
• CAS: 1210043-19-8
• 化学式: C₂₅H₄₁NO₈
• 分子量: 483.602
• InChiKey: VVUKGAZOHDSRMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.23
• 重原子数：
  34.0
• 可旋转键数：
  18.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  86.73
• 氢给体数：
  0.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  2,6-bis((2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)methyl)pyridine 在 正丁基锂 、 乙醇 、 三氟甲磺酸 、 水 、 4-甲基苯磺酸吡啶 、 sodium hydroxide 作用下， 以 四氢呋喃 、 正己烷 、 环己烷 、 甲苯 为溶剂， 反应 80.0h， 生成 (9R,12R)-9,12-ditert-butyl-3,6,15,18-tetraoxa-24-aza-9,12-diphosphabicyclo[18.3.1]tetracosa-1(24),20,22-triene
  参考文献：
  名称：

  P-Stereogenic Diphosphacrowns: Facile Incorporation of Aromatic Rings

  摘要：

  P-Stereogenic diphosphacrowns containing naphthalene and pyridine rings were synthesized. Facile incorporation of aromatic rings, and chains of different lengths, into the diphosphacrown skeleton was achieved by altering the electrophile in our previously reported synthetic method. Pyridine-containing diphosphacrown exhibited chiral recognition ability for chiral ammonium salts and carboxylic acids. This is the first example of chiral recognition using P-stereogenic diphosphacrowns. H-1 and P-31 NMR spectra indicated that the nitrogen, oxygen, and chiral phosphorus atoms contributed to the chiral recognition cooperatively.

  DOI：

  10.3987/com-15-13324
• 作为产物：
  描述：

  四氢吡喃 在 4-甲基苯磺酸吡啶 、 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 、 mineral oil 为溶剂， 生成 2,6-bis((2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)methyl)pyridine
  参考文献：
  名称：

  P-Stereogenic Diphosphacrowns: Facile Incorporation of Aromatic Rings

  摘要：

  P-Stereogenic diphosphacrowns containing naphthalene and pyridine rings were synthesized. Facile incorporation of aromatic rings, and chains of different lengths, into the diphosphacrown skeleton was achieved by altering the electrophile in our previously reported synthetic method. Pyridine-containing diphosphacrown exhibited chiral recognition ability for chiral ammonium salts and carboxylic acids. This is the first example of chiral recognition using P-stereogenic diphosphacrowns. H-1 and P-31 NMR spectra indicated that the nitrogen, oxygen, and chiral phosphorus atoms contributed to the chiral recognition cooperatively.

  DOI：

  10.3987/com-15-13324

文献信息

• Design and Synthesis of Sn-Porphyrin Based Molecular Gates
  作者：Aurélie Guenet、Ernest Graf、Nathalie Kyritsakas、Mir Wais Hosseini

  DOI：10.1021/ic902265e

  日期：2010.2.15

  The design, synthesis, and structural characterization, both in solution by 1H NMR and in the solid state by X-ray diffraction on single crystals, of a series of molecular gates based on Sn-porphyrin derivatives are presented. The molecular system is based on a porphyrin core bearing at the meso positions either phenyl or pyridyl groups as a stator, octahedral Sn(IV) cation located at the center of

  提出了一系列基于锡卟啉衍生物的分子门的设计，合成和结构表征，无论是通过1 H NMR在溶液中还是在固体中通过X射线衍射在单晶上。分子系统是基于在卟啉芯轴承内消旋位置任一苯基或吡啶基作为定子，八面体的Sn（IV）阳离子位于卟啉作为铰链的中心，和不同的手柄至Sn-连接到卟啉O轴向键。还报道了在不同酸存在下复合物的稳定性。