2-Bromo-3-hydroxy-2-methyl-propionic acid ethyl ester | 72676-20-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-Bromo-3-hydroxy-2-methyl-propionic acid ethyl ester
• 英文别名: Ethyl 2-bromo-3-hydroxy-2-methylpropanoate
• CAS: 72676-20-1
• 化学式: C₆H₁₁BrO₃
• 分子量: 211.056
• InChiKey: WSLXMICOGXFYKM-UHFFFAOYSA-N

物化性质

• 沸点：
  265.3±20.0 °C(Predicted)
• 密度：
  1.488±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基丙烯酸乙酯 在 溴 作用下， 以 水 为溶剂， 生成 乙基2,3-二溴异丁酸 、 3-Bromo-2-hydroxy-2-methyl-propionic acid ethyl ester 、 2-Bromo-3-hydroxy-2-methyl-propionic acid ethyl ester
  参考文献：
  名称：

  不饱和脂肪羧酸衍生物水溶液中溴加成的动力学和机理

  摘要：

  本文讨论了在 22、30、38、46 和 54 °C 下，在添加溴离子存在下，溴与不饱和化合物的加成动力学。所用基材为丙烯酰胺（AAm）、丙烯酸甲酯（MA）、丙烯酸乙酯（EA）、丙烯酸丁酯（BA）、丙烯酸叔丁酯（tBA）、甲基丙烯酰胺（MAAm）、甲基丙烯酸甲酯（MMA）、甲基丙烯酸乙酯（EMA） )、巴豆酸甲酯 (MC) 和巴豆酸乙酯 (EC)。通过电位测定法跟踪动力学。计算并比较激活参数（ΔH\eweq、ΔS\eweq和ΔG\eweq）。溴代醇与二溴化物的产物比率的估计表明产物形成与底物的反应性之间不存在任何相关性。观察到的参数与建议的反应机制有关。

  DOI：

  10.1246/bcsj.57.1394

文献信息

• ATOM TRANSFER RADICAL POLYMERIZATION PROCESS
  申请人：CARNEGIE MELLON UNIVERSITY

  公开号：EP1725590A1

  公开（公告）日：2006-11-29
• Atom Transfer Radical Polymerization Process
  申请人：Matyjaszewski Krzysztof

  公开号：US20070276101A1

  公开（公告）日：2007-11-29

  Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprise reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.
• US7893174B2
  申请人：——

  公开号：US7893174B2

  公开（公告）日：2011-02-22
• [EN] ATOM TRANSFER RADICAL POLYMERIZATION PROCESS<br/>[FR] PROCEDE DE POLYMERISATION RADICALAIRE PAR TRANSFERT D'ATOME
  申请人：UNIV CARNEGIE MELLON

  公开号：WO2005087819A1

  公开（公告）日：2005-09-22

  Embodiments of the polymerization process of the present invention are directed to polymerizing free radically polymerizable monomers in the presence of a polymerization medium initially comprising at least one transition metal catalyst and an atom transfer radical polymerization initiator. The polymerization medium may additionally comprise a reducing agent. The reducing agent may be added initially or during the polymerization process in a continuous or intermittent manner. The polymerization process may further comprise reacting the reducing agent with at least one of the transition metal catalyst in an oxidized state and a compound comprising a radically transferable atom or group to form a compound that does not participate significantly in control of the polymerization process. Embodiments of the present invention comprise reacting a reducing agent with at least one of catalyst in an oxidized state and a compound comprising a radically transferable atom or group to initiate and/or maintain catalytic activity throughout the polymerization process.