3-甲基磺酰基-2,2’,4’,5,5’-五氯联苯 | 66640-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-甲基磺酰基-2,2’,4’,5,5’-五氯联苯
• 英文名称: 3-methanesulfonyl-2,2',4',5,5'-pentachlorobiphenyl
• 英文别名: 2,5,2',4', 5'-pentachloro-3-methanesulfonylbiphenyl；3'-methylsulfonyl-2,2',4,5,5'-pentachlorobiphenyl；3-methylsulfonyl-2,2',4',5,5'-pentachlorobiphenil；3-methylsulfonyl-2,5,2',4',5'-pentachlorobiphenyl；2,2'4,5,5'-pentachlorobiphenyl-3'-methyl sulfone；3-methylsulfonyl-2,2',4,5,5'-pentachlorobiphenyl；1,1'-Biphenyl, 2,2',4',5,5'-pentachloro-3-(methylsulfonyl)-；2,5-dichloro-1-methylsulfonyl-3-(2,4,5-trichlorophenyl)benzene
• CAS: 66640-60-6
• 化学式: C₁₃H₇Cl₅O₂S
• 分子量: 404.528
• InChiKey: PYZHICPTPGJNJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-二氯苯硫酚 在 bis-triphenylphosphine-palladium(II) chloride 、 10% palladium on active carbon sodium hydroxide 、 copper(l) iodide 、 sodium hypophosphite 、 三苯胂 、 potassium nitrate 、 sodium iodide 、 sodium nitrite 作用下， 以 四氢呋喃 、 乙醇 、 硫酸 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 28.5h， 生成 3-甲基磺酰基-2,2’,4’,5,5’-五氯联苯
  参考文献：
  名称：

  An alternative synthesis of chlorinated biphenyl methylsulfonyl metabolites

  摘要：

  Published methods of synthesizing chlorinated biphenyl methylsulfones require the separation of a complex mixture of impurities and isomers using both normal and reverse phase HPLC. Even with semi-preparative scale equipment, the process is tedious and time-consuming. In this report, the palladium-catalyzed addition of an aryl iodide to an aryl trimethylstannane has been exploited to produce these compounds in high purity (greater than or equal to 99%) using conventional techniques of purification. The reaction has been demonstrated for a group of methylsulfonyl CBs representing 0 to 3 ortho-chlorine interactions between the biphenyl rings and with the methylsulfonyl group at either the 3- or 4-position.

  DOI：

  10.1016/0045-6535(95)00331-2

文献信息

• An alternative synthesis of chlorinated biphenyl methylsulfonyl metabolites
  作者：Richard D. Mortimer、W.Harvey Newsome

  DOI：10.1016/0045-6535(95)00331-2

  日期：1996.3

  Published methods of synthesizing chlorinated biphenyl methylsulfones require the separation of a complex mixture of impurities and isomers using both normal and reverse phase HPLC. Even with semi-preparative scale equipment, the process is tedious and time-consuming. In this report, the palladium-catalyzed addition of an aryl iodide to an aryl trimethylstannane has been exploited to produce these compounds in high purity (greater than or equal to 99%) using conventional techniques of purification. The reaction has been demonstrated for a group of methylsulfonyl CBs representing 0 to 3 ortho-chlorine interactions between the biphenyl rings and with the methylsulfonyl group at either the 3- or 4-position.