sodium hypophosphite | 10039-56-2

• 物质功能分类: 无机化工 - 无机盐 - 磷化物、金属的磷酸、偏磷酸、次磷酸和焦磷酸盐
• 分子结构分类: 无机化合物 - 混合金属/非金属化合物 - 碱金属有机物
• 英文名称: sodium hypophosphite
• 英文别名: sodium phosphinate；Sodium;dioxidophosphanium；sodium;dioxidophosphanium
• CAS: 10039-56-2
• 化学式: H₂O₂P*Na
• 分子量: 87.9782
• InChiKey: SIGUVTURIMRFDD-UHFFFAOYSA-M

物化性质

• 熔点：
  90°C
• 密度：
  0.8
• 溶解度：
  1000g/l(20°C)
• 稳定性/保质期：
  具有强烈的还原性，与氯酸盐和氧化剂接触时可能发生爆炸。

计算性质

• 辛醇/水分配系数(LogP)：
  -5.05
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• TSCA：
  Yes
• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 海关编码：
  2835100000
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  SZ5640000
• 储存条件：
  | 室温 |

SDS

Name:	Sodium Hypophosphite Monohydrate 99% Material Safety Data Sheet
Synonym:	Phosphinic Acid Sodium Salt Monohydrate; Sodium Hypophosphite Monohydrat
CAS:	10039-56-2

Section 1 - Chemical Product MSDS Name:Sodium Hypophosphite Monohydrate 99% Material Safety Data Sheet
Synonym:Phosphinic Acid Sodium Salt Monohydrate; Sodium Hypophosphite Monohydrat

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
10039-56-2	Sodium Hypophosphite Monohydrate	>98	unlisted

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

---

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.
Ingestion:
Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical aid.
Notes to Physician:

---

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Combustion generates toxic fumes.
Decomposes generating flammable and toxic phosphine gas.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

---

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry, well-ventilated area away from incompatible substances.

---

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

---

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Appearance: white
Odor: odorless
pH: Not available.
Vapor Pressure: Negligible
Viscosity: Not available.
Boiling Point: Decomposes
Freezing/Melting Point: 90 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature: >90 C
Solubility in water: Soluble in water
Specific Gravity/Density: 0.8
Molecular Formula: NaH2PO2.H20
Molecular Weight: 87.9764

---

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable. However, may decompose if heated.
Conditions to Avoid:
High temperatures, incompatible materials, dust generation, moisture.
Incompatibilities with Other Materials:
Strong oxiziders, moisture.
Hazardous Decomposition Products:
Phosphine, irritating and toxic fumes and gases, toxic fumes of sodium oxide, hydrogen gas.
Hazardous Polymerization: Has not been reported.

---

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 10039-56-2: SZ5640000 LD50/LC50:
CAS# 10039-56-2: Oral, rat: LD50 = 7640 mg/kg.
Carcinogenicity:
Sodium Hypophosphite Monohydrate - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION
Other No information available.

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Dangerous Goods Code:
UN Number:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 10039-56-2: 2
United Kingdom Occupational Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 10039-56-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 10039-56-2 is not listed on the TSCA inventory.
It is for research and development use only.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

根据提供的信息,次磷酸钠具有多种用途和应用领域:

1. 电子工业:用作电磁屏蔽处理

2. 化学镀:作为金属和非金属材料表面金属化的还原剂,用于化学镀层如化学镀镍

3. 塑料工业:用作工程塑料的稳定剂,如聚氯乙烯、聚碳酸酯等

4. 食品工业:食品添加剂,可用于熏肉、腌肉等

5. 营养业:作为营养增强剂

6. 纸浆业:可提高硫酸盐纸浆收率和质量

7. 废水处理:酸性废水脱砷

8. 农业:植物杀菌剂

9. 金属加工:普通钢材不锈钢化的主要原料

10. 有机合成:还原剂,如某些硝基化合物的还原

需要注意的是:

• 次磷酸钠在干燥状态下相对稳定,但遇强热会爆炸
• 加热超过200℃时分解并放出磷化氢等有毒气体
• 生产过程中涉及到多种有毒有害物质,需密闭、管道化生产

总的来说,次磷酸钠是一种多功能的化学品,在多个行业都有广泛的应用。但由于其易燃易爆和毒性,使用和储存时需要严格遵守安全规范。

反应信息

• 作为反应物：
  描述：

  sodium hypophosphite 在 盐酸 作用下， 以 甲苯 为溶剂， 以83%的产率得到次磷酸
  参考文献：
  名称：

  镍催化次磷酸钠参与炔烃直接氢化磷酸化生成 H-次膦酸盐

  摘要：

  传统的亚膦酸酯合成方法使用三氯化磷 (PCl 3 ) 作为磷源，导致过程污染严重且能源密集。寻找一种既温和又环保的替代方法是现代化学中一项具有挑战性但回报丰厚的任务。在此，我们使用无机含磷物质 NaH 2 PO 2作为磷源，直接参与镍催化的选择性炔烃氢膦酰化反应。这种转变是在室温下以多组分方式实现的，最重要的是，H- 生成的次膦酸盐产品是一种高级中间体，可以很容易地转化为多种次膦酸盐衍生物，包括带有新 P-C、P-S、P-N、P-Se 和 P-O 键的衍生物，从而提供一种补充方法经典的次膦酸酯合成技术。

  DOI：

  10.1021/acs.joc.2c02741
• 作为产物：
  描述：

  phosphorus 在 sodium hydroxide 、 水 作用下， 生成 sodium hypophosphite
  参考文献：
  名称：

  Oxidation of Phosphorus with Water at High Temperature and Pressure in the Presence of Alkali. The Production of Phosphorous Acid

  摘要：

  DOI：

  10.1021/ja01305a020
• 作为试剂：
  描述：

  2-(1-bromocarbazol-9-yl)acetic acid 在 吡啶 、 盐酸 、 甲醇 、 1,1'-双(二苯基膦)二茂铁 、 sodium tetrahydroborate 、 tris-(dibenzylideneacetone)dipalladium(0) 、 sodium hypophosphite 、 水 、 溶剂黄146 、 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  [EN] PROTEIN DEGRADATION AGENT
  [FR] AGENT DE DÉGRADATION DE PROTÉINE
  [ZH] 一种蛋白降解剂

  摘要：

  涉及一类蛋白降解剂及其制备方法和用途，所述蛋白降解剂可降解包括c-Myc蛋白在内的多种蛋白，因此，可用于包括c-Myc蛋白在内的多种蛋白失调相关疾病，如癌症、心脑血管疾病、病毒感染相关疾病等的预防和治疗。

  公开号：

  WO2024027694A1

文献信息

• Highly efficient and selective photocatalytic reduction of nitroarenes using the Ni₂P/CdS catalyst under visible-light irradiation
  作者：Wen-Zheng Gao、Yong Xu、Yong Chen、Wen-Fu Fu

  DOI：10.1039/c5cc04030b

  日期：——

  A highly efficient Ni₂P/CdS photocatalytic system in water for selective nitro reduction to amino organics and the reaction mechanism were presented clearly.

  在水中，一种高效的Ni₂P/CdS光催化系统可选择性地将硝基还原为氨基有机化合物，并清晰地展示了反应机制。
• Organophosphorus Chemistry without PCl₃: A Bridge from Hypophosphorous Acid to H-Phosphonate Diesters
  作者：Henry C. Fisher、Lucie Prost、Jean-Luc Montchamp

  DOI：10.1002/ejoc.201301412

  日期：2013.12

  A process for the conversion of hypophosphorous acid (H3PO2, HPA) and alcohols into various H-phosphonate diesters [(RO)2P(O)H] is described. The new reaction provides a missing bridge between HPA and important H-phosphonates, completely avoiding the use of PCl3. Nickel chloride or nickel on silica catalyze the oxidative phosphorylation of alkyl phosphinates with various alcohols or water. The reaction

  描述了将次磷酸 (H3PO2, HPA) 和醇转化为各种 H-膦酸二酯 [(RO)2P(O)H] 的过程。新反应在 HPA 和重要的 H-膦酸盐之间提供了一个缺失的桥梁，完全避免了 PCl3 的使用。氯化镍或二氧化硅上的镍催化烷基次膦酸盐与各种醇或水的氧化磷酸化。该反应是原子经济的，避免了废物的形成。完全避免了以前对氯和碱的需求。
• Synthesis of H-Phosphonate Intermediates and Their Use in Preparing the Herbicide Glyphosate
  申请人：Texas Christian University

  公开号：US20140303394A1

  公开（公告）日：2014-10-09

  The esterfication of hypophosphorous acid is followed by reaction with another molecule of alcohol under the action of a nickel catalyst to provide a green method for the preparation of H-phosphonate diesters. This method avoids the need for any stoichiometric chlorine unlike those based on phosphorous trichloride.

  亚磷酸酯化后，在镍催化剂的作用下，与另一分子醇发生反应，提供了一种绿色方法来制备H-膦酸二酯。该方法避免了基于三氯化磷的方法中需要任何等化物氯的需求。
• A copper nitride catalyst for the efficient hydroxylation of aryl halides under ligand-free conditions
  作者：Hang Xu、Sho Yamaguchi、Takato Mitsudome、Tomoo Mizugaki

  DOI：10.1039/d1ob00768h

  日期：——

  Copper nitride (Cu3N) was used as a heterogeneous catalyst for the hydroxylation of aryl halides under ligand-free conditions. The cubic Cu3N nanoparticles showed high catalytic activity, comparable to those of conventional Cu catalysts with nitrogen ligands, demonstrating that the nitrogen atoms in Cu3N act as functional ligands that promote hydroxylation.

  氮化铜 (Cu 3 N) 被用作在无配体条件下芳基卤化物羟基化的非均相催化剂。立方Cu 3 N 纳米颗粒表现出高催化活性，与具有氮配体的常规Cu 催化剂相当，表明Cu 3 N 中的氮原子充当促进羟基化的功能性配体。
• Noncrystalline NiPB nanotubes for hydrogenation of p-chloronitrobenzene
  作者：Min Mo、Ling Han、Jiangang Lv、Yan Zhu、Luming Peng、Xuefeng Guo、Weiping Ding

  DOI：10.1039/b922256a

  日期：——

  High quality noncrystalline NiPB nanotubes were synthesized and exhibited high efficiency for the catalytic hydrogenation of p-chloronitrobenzene due to the characteristic confinement effect of the nanotubes.

  高质量的非晶态NiPB纳米管被合成，并由于纳米管特有的限域效应，在催化对氯硝基苯氢化反应中表现出高效率。