5-(5-bromo-2-hydroxybenzylidene)pyrimidin-2,4,6-trione | 297148-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(5-bromo-2-hydroxybenzylidene)pyrimidin-2,4,6-trione
• 英文别名: 5-[(5-Bromo-2-hydroxyphenyl)methylidene]-1,3-diazinane-2,4,6-trione
• CAS: 297148-93-7
• 化学式: C₁₁H₇BrN₂O₄
• 分子量: 311.092
• InChiKey: BVGKJEWTDAMYSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  巴比妥酸 、 5-溴水杨醛 以 甲醇 为溶剂， 反应 4.0h， 以83%的产率得到5-(5-bromo-2-hydroxybenzylidene)pyrimidin-2,4,6-trione
  参考文献：
  名称：

  Goudgaon; Patil; Rahaman, Journal of the Indian Chemical Society, 2010, vol. 87, # 6, p. 743 - 748

  摘要：

  DOI：

文献信息

• Medicinal drug with activity against gram positive bacteria, mycobacteria and fungi
  申请人：Levina Elizabeth

  公开号：US10265318B2

  公开（公告）日：2019-04-23

  A medicinal drug is provided with activity against gram positive bacteria, mycobacteria and fungi characterized in that it is a compound of the class of pyrimidine derivatives of salicylic aldehyde and perhydropyrimidine-2,4,6-triones selected from a group consisting of tautomeric forms, salt forms, and a cyclic form of pyrylium salts, and with the general formula: where X1, X3 are selected from the group containing: H, halogen; NO2; X2, X4 are selected from the group containing: H, halogen; Z is selected from the group containing: O, NNH2, NOH, perhydropyrimidine-5-ylidene-2,4.6-trione, perhydropyrimidine-5-ylidene-2,4.6-trione, substituted at the nitrogen atom with alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K. Further, methods for treating infections, tonsillitis, pneumonia, or wound infections caused by Gram-positive bacteria, mycobacteria and fungi are provided using a therapeutically effective amount of the compound.

  提供了一种对革兰氏阳性菌、分枝杆菌和真菌具有活性的药物，其特征在于它是一种水杨醛和过氢嘧啶-2,4,6-三酮的嘧啶衍生物类化合物，该化合物从同分异构体、盐类和环状嘧啶盐组成的组中选出，通式为 其中 X1、X3 选自以下组别H、卤素 X2、X4 选自包含以下物质的组H、卤素； Z 选自包含以下物质的组O、NNH2、NOH、全氢嘧啶-5-亚基-2,4.6-三酮、全氢嘧啶-5-亚基-2,4.6-三酮，在氮原子上被烷基、芳基或芳烷基取代； Y 选自以下组别H、Na、Li、K。 此外，还提供了使用治疗有效量的化合物治疗革兰氏阳性菌、分枝杆菌和真菌引起的感染、扁桃体炎、肺炎或伤口感染的方法。
• Medicinal Drug with Activity against Gram Positive Bacteria, Mycobacteria and Fungi
  申请人：Levina Elizabeth

  公开号：US20170035758A1

  公开（公告）日：2017-02-09

  A medicinal drug is provided with activity against gram positive bacteria, mycobacteria and fungi characterized in that it is a compound of the class of pyrimidine derivatives of salicylic aldehyde and perhydropyrimidine-2,4,6-triones selected from a group consisting of tautomeric forms, salt forms, and a cyclic form of pyrylium salts, and with the general formula: where X1, X3 are selected from the group containing: H, halogen; NO 2 ; X2, X4 are selected from the group containing: H, halogen; Z is selected from the group containing: O, NNH 2 , NOH, perhydropyrimidine-5-ylidene-2,4.6-trione, perhydropyrimidine-5-ylidene-2,4.6-trione, substituted at the nitrogen atom with alkyl, aryl or aralkyl group; Y is selected from the group containing: H, Na, Li, K. Further, methods for treating infections, tonsillitis, pneumonia, or wound infections caused by Gram-positive bacteria, mycobacteria and fungi are provided using a therapeutically effective amount of the compound.
• US9433623B2
  申请人：——

  公开号：US9433623B2

  公开（公告）日：2016-09-06
• [EN] MEDICINAL DRUG WITH ACTIVITY AGAINST GRAM POSITIVE BACTERIA, MYCOBACTERIA AND FUNGI<br/>[FR] MÉDICAMENT AYANT UNE ACTIVITÉ CONTRE LES BACTÉRIES GRAM POSITIF, LES MYCOBACTÉRIES ET LES CHAMPIGNONS
  申请人：LEVINA ELIZABETH

  公开号：WO2014042647A1

  公开（公告）日：2014-03-20

  The invention relates to chemistry and pharmacology, in paliicular to synthetic biologically active substances of the pynmidine series that have antimicrobial activity, and to the method of synthesis thereof. According to the invention there is provided a new substance with activity against gram positive bacteria, mycobacteria and fungi characterized in that it constitutes 5-(2-hydroxybenzylidene) derivatives of the pyrimidinone series with the general formula 1 where XI, X3 are selected from the group containing: H, halogen; N02;X2, X4 are selected from the group containing: H, halogen: Z is selected from the group containing: 0, NNH2, NOH, pei†iydropyrimidine-5-ytidene-2,4.6-trione, perhyd.ropyrimidine-5- ylidene-2,4.6-trione, substituted at the nitrogen atom With alkyl, aryl or aralkyl group;Y is selected from the group containing: H, Na, Li, K