(Rs)-2-methyl-N-((S)-1-(2-((trimethylsilyl)ethynyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide | 1560811-51-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Rs)-2-methyl-N-((S)-1-(2-((trimethylsilyl)ethynyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide
• CAS: 1560811-51-9
• 化学式: C₁₉H₂₉NOSSi
• 分子量: 347.597
• InChiKey: NUTGSNGXTARYSX-PGRDOPGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.58
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (Rs)-2-methyl-N-((S)-1-(2-((trimethylsilyl)ethynyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以61%的产率得到(Rs)-N-((S)-1-(2-ethynylphenyl)but-3-en-1-yl)-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

  摘要：

  Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

  DOI：

  10.1021/ol500142c
• 作为产物：
  描述：

  2-碘苯甲醛 在 bis-triphenylphosphine-palladium(II) chloride 、 titanium(IV) tetraethanolate 、 copper(l) iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 三乙胺 为溶剂， 反应 21.0h， 生成 (Rs)-2-methyl-N-((S)-1-(2-((trimethylsilyl)ethynyl)phenyl)but-3-en-1-yl)propane-2-sulfinamide
  参考文献：
  名称：

  Asymmetric Allylation/Pauson–Khand Reaction: A Simple Entry to Polycyclic Amines. Application to the Synthesis of Aminosteroid Analogues

  摘要：

  Asymmetric allylation of o-iodoarylsulfinylimines has been achieved in high diastereoselectivities. The thus-obtained o-iodoarylhomoallylic sulfinamides participate in a subsequent Sonogashira coupling followed by a diastereoselective intramolecular Pauson-Khand reaction. In this way, tricyclic amines showing a unique benzo-fused indenyl backbone were obtained. The methodology has been applied to the synthesis of amino steroid analogues.

  DOI：

  10.1021/ol500142c