methyl (2S,4S)-4-hydroxypiperidine-2-carboxylate | 1103929-08-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S,4S)-4-hydroxypiperidine-2-carboxylate
• 英文别名: methyl 4(S)-hydroxypiperidine-2(S)-carboxylate
• CAS: 1103929-08-3
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: XYDFSCGFCFYWNY-WDSKDSINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl (2S,4S)-4-hydroxypiperidine-2-carboxylate 在 盐酸 、 水 作用下， 反应 2.0h， 以60%的产率得到(2S,4S)-4-羟基-2-哌啶羧酸
  参考文献：
  名称：

  Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes

  摘要：

  Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [H-3]-SUC or [H-3]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.083
• 作为产物：
  描述：

  methyl 4(S)-hydroxy-1-[1(R)-phenylethyl]piperidine-2(S)-carboxylate 在 palladium(II) hydroxide/carbon 、 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以75%的产率得到methyl (2S,4S)-4-hydroxypiperidine-2-carboxylate
  参考文献：
  名称：

  Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes

  摘要：

  Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [H-3]-SUC or [H-3]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.083

文献信息

• [EN] CYTOTOXIC AGENTS<br/>[FR] AGENTS CYTOTOXIQUES
  申请人：FEMTOGENIX LTD

  公开号：WO2019043417A1

  公开（公告）日：2019-03-07

  The invention relates to a compound of formula (I) or formula (II) or pharmaceutically acceptable salts, solvates, tautomers, stereoisomers or mixtures thereof; which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate and in the treatment of proliferative diseases.

  该发明涉及公式（I）或公式（II）的化合物，或其药学上可接受的盐、溶剂合物、互变异构体、立体异构体或其混合物；这些化合物可用作药物，特别是作为抗增殖剂，并用作抗体-药物结合物中的药物，用于治疗增殖性疾病。
• Validation of high-affinity binding sites for succinic acid through distinguishable binding of gamma-hydroxybutyric acid receptor-specific NCS 382 antipodes
  作者：Tünde Molnár、Júlia Visy、Ágnes Simon、István Moldvai、Eszter Temesvári-Major、Gábor Dörnyei、Erzsébet Kútiné Fekete、Julianna Kardos

  DOI：10.1016/j.bmcl.2008.08.083

  日期：2008.12

  Gamma-hydroxybutyric acid (GHB) binding to multiple sites for the tricarboxylic acid cycle intermediate succinic acid (SUC) has been disclosed recently. In order to better characterize these targets, distinguishable binding of GHB receptor-specific NCS 382 antipodes to [H-3]-SUC or [H-3]-GHB labelled sites in rat brain synaptic membranes was explored. Eutomer binding parameters suggest identity of the high-affinity target for SUC with a synaptic GHB receptor subtype. (C) 2008 Elsevier Ltd. All rights reserved.