2-Methyl-5-hydroxytryptamine hydrochloride | 845861-49-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Methyl-5-hydroxytryptamine hydrochloride
• 英文别名: 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol;hydrochloride
• CAS: 845861-49-6
• 化学式: C11H15ClN2O
• 分子量: 226.7
• InChiKey: ZNVRHQPXSBWLQP-UHFFFAOYSA-N

物化性质

• 熔点：
  225.5-227.0 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  62
• 氢给体数：
  4
• 氢受体数：
  2

制备方法与用途

生物活性

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) 是一种有效的选择性 5-HT3 受体激动剂。2-Methyl-5-HT hydrochloride 显示出抗抑郁样作用。

靶点

5-HT 3 Receptor

体内研究

2-Methyl-5-HT hydrochloride (2-Methyl-5-hydroxytryptamine hydrochloride) (i.p.; 3 mg/kg; 45 minutes) significantly decreases time of immobility as compared to controls thus showing anti-depressive-like effects.

Animal Model:	Male Sprague-Dawley rats
Dosage:	3 mg/kg
Administration:	I.p.; 45 minutes
Result:	Significantly decreased time of immobility thus showing anti-depressive-like effects.

文献信息

• TREATMENT OF PAIN WITH SEROTONIN-3 RECEPTOR AGONIST
  申请人：Osaka University

  公开号：EP3646886A1

  公开（公告）日：2020-05-06

  The present invention provides a drug for preventing or treating chronic pain and a method for preventing or treating chronic pain. A pharmaceutical composition comprising a serotonin-3 receptor agonist such as a compound represented by the following formula (I): [wherein: m is an integer of 1 to 4; and R1 is each independently selected from the group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted with 1 to 3 halogen atom(s), a methoxy group optionally substituted with 1 to 3 halogen atom(s), and a methylthio group optionally substituted with 1 to 3 halogen atom(s)] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The above pharmaceutical composition is also useful for preventing or treating acute pain. Further, the present invention provides a method for screening a compound for preventing or treating chronic pain, the method comprising measuring a serotonin-3 receptor agonist activity.

  本发明提供了一种预防或治疗慢性疼痛的药物和一种预防或治疗慢性疼痛的方法。一种药物组合物，包含血清素-3 受体激动剂，例如由下式（I）代表的化合物： [其中：m 为 1 至 4 的整数；且 R1 各自独立地选自由氢原子、卤素原子、任选被 1 至 3 个卤素原子取代的甲基、任选被 1 至 3 个卤素原子取代的甲氧基和任选被 1 至 3 个卤素原子取代的甲硫基组成的组]或其药学上可接受的盐，可用于预防或治疗慢性疼痛。上述药物组合物也可用于预防或治疗急性疼痛。此外，本发明还提供了一种用于筛选预防或治疗慢性疼痛的化合物的方法，该方法包括测定5-羟色胺-3受体激动剂的活性。
• Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of neoplasia
  申请人：Masferrer L. Jaime

  公开号：US20050085477A1

  公开（公告）日：2005-04-21

  The present invention provides compositions and methods for the treatment of neoplasia in a subject. More particularly, the invention provides a combination therapy for the treatment of a neoplasia comprising the administration to a subject of a serotonin modulating agent in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了用于治疗受试者肿瘤的组合物和方法。更具体地说，本发明提供了一种治疗肿瘤的组合疗法，包括向受试者施用5-羟色胺调节剂与环氧化酶-2选择性抑制剂。
• Agonists and antagonists of 5h3-like receptors of invertebrates as pesticides
  申请人：Trowell Charles Stephen

  公开号：US20050054680A1

  公开（公告）日：2005-03-10

  The present invention provides compositions and methods for controlling an helminth or arthropod pest. In a preferred embodiment of the invention provided herein, the compositions comprise compounds which alter the 5-HT 3 receptor of the pest. Also claimed are various esters of N-methyl 8-azabicyclo[3.2.1]octan-3-ol (tropan-3-yl esters) and an assay for identifying and/or assessing a helminth and/or arthropod control compound by determining the ability of a candidate compound to modulate the activity of a helminth or arthropod 5-HT 3 receptor.

  本发明提供了控制蠕虫或节肢动物害虫的组合物和方法。在本文提供的本发明的一个优选实施方案中，组合物包括改变 5-HT 3 受体的化合物。本发明还要求得到 N-甲基 8-氮杂双环[3.2.1]辛烷-3-醇的各种酯（托坦-3-基酯），以及通过测定候选化合物调节螺旋体或节肢动物 5-HT 3 受体的能力。
• Compositions of a cyclooxygenase-2 selective inhibitor and a serotonin-modulating agent for the treatment of central nervous system damage
  申请人：Stephenson T. Diane

  公开号：US20050080084A1

  公开（公告）日：2005-04-14

  The present invention provides compositions and methods for the treatment of central nervous system damage in a subject. More particularly, the invention provides a combination therapy for the treatment of a central nervous system ischemic condition or a central nervous system traumatic injury comprising the administration to a subject of a serotonin-modulating agent in combination with a cyclooxygenase-2 selective inhibitor.

  本发明提供了治疗受试者中枢神经系统损伤的组合物和方法。更具体地说，本发明提供了一种用于治疗中枢神经系统缺血性疾病或中枢神经系统创伤性损伤的组合疗法，该疗法包括向受试者施用血清素调节剂与环氧化酶-2 选择性抑制剂。
• AGONISTS AND ANTAGONISTS OF 5H 3?-LIKE RECEPTORS OF INVERTEBRATE S AS PESTICIDES
  申请人：COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

  公开号：EP1423006A1

  公开（公告）日：2004-06-02