6,12-Dioxo-5,6,11,12-tetrahydro-dibenzo[b,f]azocine-9-carboxylic acid butylamide | 875896-27-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: 6,12-Dioxo-5,6,11,12-tetrahydro-dibenzo[b,f]azocine-9-carboxylic acid butylamide
• CAS: 875896-27-8
• 化学式: C₂₀H₂₀N₂O₃
• 分子量: 336.39
• InChiKey: OTGUBGAVUYCKNO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  6,12-Dioxo-5,6,11,12-tetrahydro-dibenzo[b,f]azocine-9-carboxylic acid butylamide 在 Rh on carbon 盐酸 、 dimethyl sulfide borane 、 氢气 作用下， 以 甲醇 、 乙醇 、 二氯甲烷 为溶剂， 生成 5-Acetyl-5,6,11,12-tetrahydro-dibenzo[b,f]azocine-9-carboxylic acid butylamide
  参考文献：
  名称：

  Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

  摘要：

  A novel series of 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17 beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.039
• 作为产物：
  描述：

  5,10-Dihydro-indeno[1,2-b]indole-2-carboxylic acid butylamide 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成 6,12-Dioxo-5,6,11,12-tetrahydro-dibenzo[b,f]azocine-9-carboxylic acid butylamide
  参考文献：
  名称：

  Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3

  摘要：

  A novel series of 17 beta-hydroxysteroid dehydrogenase type 3 (17 beta-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17 beta-HSD3 in cell-free enzymatic as well as in cell-based transcriptional reporter assays. (C) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.12.039