4-benzyloxy-2'-hydroxy-5-methoxy-biphenyl-3-carbaldehyde | 1134103-74-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-benzyloxy-2'-hydroxy-5-methoxy-biphenyl-3-carbaldehyde
• 英文别名: 5-(2-Hydroxyphenyl)-3-methoxy-2-phenylmethoxybenzaldehyde
• CAS: 1134103-74-4
• 化学式: C₂₁H₁₈O₄
• 分子量: 334.372
• InChiKey: TXIZKHUGBXVXMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-benzyloxy-2'-hydroxy-5-methoxy-biphenyl-3-carbaldehyde 、 对甲苯磺酸三缩乙二醇单甲醚酯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以88%的产率得到4-benzyloxy-5-methoxy-2'-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl-3-carbaldehyde
  参考文献：
  名称：

  Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes

  摘要：

  The synthesis and antioxidant activity of oligo( ethylene glycol)-modified manganese salen complexes are reported. Their SOD activities were similar and 2- to 3-fold more potent than the standard compound EUK-134. Their catalase-like activity was lower than that of EUK-134 in the initial conversion rate; however, some analogs exhibited a better catalytic turnover number. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.063
• 作为产物：
  描述：

  2-羟基苯硼酸 、 2-(benzyloxy)-5-bromo-3-methoxybenzaldehyde 在 potassium phosphate 、 三苯基膦钯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以85%的产率得到4-benzyloxy-2'-hydroxy-5-methoxy-biphenyl-3-carbaldehyde
  参考文献：
  名称：

  Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes

  摘要：

  The synthesis and antioxidant activity of oligo( ethylene glycol)-modified manganese salen complexes are reported. Their SOD activities were similar and 2- to 3-fold more potent than the standard compound EUK-134. Their catalase-like activity was lower than that of EUK-134 in the initial conversion rate; however, some analogs exhibited a better catalytic turnover number. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.063