2-Methyl-n-[2-(1h-pyrazol-4-yl)-1h-indol-5-yl]propanamide | 827318-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-Methyl-n-[2-(1h-pyrazol-4-yl)-1h-indol-5-yl]propanamide
• CAS: 827318-27-4
• 化学式: C₁₅H₁₆N₄O
• 分子量: 268.31
• InChiKey: BKQQVZLUQJISIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  73.6
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
  申请人：Berta Gavina Daniela

  公开号：US20050032869A1

  公开（公告）日：2005-02-10

  Pyrazolyl-indole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

  本发明公开了式（I）中定义的吡唑基吲哚衍生物及其药学上可接受的盐，以及它们的制备方法和包括它们的药物组合物；本发明的化合物可能在治疗与蛋白激酶活性失调相关的疾病，如癌症方面有用。
• PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia Italia S.p.A.

  公开号：EP1648884A2

  公开（公告）日：2006-04-26
• [EN] PYRAZOLYL-INDOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] DERIVES DE PYRAZOLYL-INDOLE ACTIFS EN TANT QU'INHIBITEURS DE KINASE, PROCEDE DE PREPARATION CORRESPONDANT ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA ITALIA SPA

  公开号：WO2005005414A2

  公开（公告）日：2005-01-20

  Pyrazolyl-indole derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.