N-(9,10-dioxophenanthren-2-yl)-2-phenoxyacetamide | 867376-01-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: N-(9,10-dioxophenanthren-2-yl)-2-phenoxyacetamide
• CAS: 867376-01-0
• 化学式: C₂₂H₁₅NO₄
• 分子量: 357.365
• InChiKey: INNAPNUKYFYLHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pten Inhibitors
  申请人：Garlich R. Joseph

  公开号：US20070203098A1

  公开（公告）日：2007-08-30

  The therapeutic use of inhibitors of PTEN activity in the treatment of PTEN-mediated diseases, conditions, and injuries is disclosed.

  本文揭示了使用PTEN活性抑制剂治疗PTEN介导的疾病、病况和损伤的治疗方法。
• Promoting Axon Regeneration in the Adult CNS through Control of Protein Translation
  申请人：Children's Medical Center Corporation

  公开号：EP2502623B1

  公开（公告）日：2016-04-06
• PTEN Inhibitors Treat Neutropenia-Associated Pneumonia
  申请人：Luo Hongbo R.

  公开号：US20110002877A1

  公开（公告）日：2011-01-06

  Neutropenia-associated pneumonia is treated with a therapeutically effective amount of a small-molecule PTEN inhibitor. The method may further include detecting a resultant alleviation of the neutropenia-associated pneumonia, and/or diagnosing the neutropenia-associated pneumonia. The patient may be undergoing anti-cancer chemotherapy and/or radiotherapy, and the methods may further include the step of treating the patient with broad-spectrum antibiotic therapy or granulocyte colony-stimulating factor (G-CSF) therapy.
• PROMOTING AXON REGENERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION
  申请人：Children's Medical Center Corporation

  公开号：US20130123228A1

  公开（公告）日：2013-05-16

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.
• PROMOTING AXON RENEGERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20140213609A1

  公开（公告）日：2014-07-31

  Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.