tert-butyl 3-oxo-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepine-4-carboxylate | 888022-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: tert-butyl 3-oxo-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepine-4-carboxylate
• 英文别名: 1,1-Dimethylethyl 1,2,3,5-tetrahydro-3-oxo-4H-1,4-benzodiazepine-4-carboxylate；tert-butyl 3-oxo-2,5-dihydro-1H-1,4-benzodiazepine-4-carboxylate
• CAS: 888022-43-3
• 化学式: C₁₄H₁₈N₂O₃
• 分子量: 262.309
• InChiKey: RFRVYHRGOGMUJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,3,4,5-四氢-1H-1,4-苯并二氮杂-3-酮 、 二碳酸二叔丁酯 在 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 生成 tert-butyl 3-oxo-1,2,3,5-tetrahydrobenzo[e]-1,4-diazepine-4-carboxylate
  参考文献：
  名称：

  AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH

  摘要：

  本发明提供了具有V2受体激动作用的芳香酰胺衍生物，可用作治疗或预防尿崩症、夜尿症、夜间遗尿、膀胱过度活跃或类似疾病的药物，并由通式（I）表示： 其中R1代表氢原子或可能具有取代基的C1-6烷基基团，R2是氢原子或C1-6烷基基团，R3是氢原子、C1-6烷基基团或类似物，R4、R5和R6独立地是氢原子、卤原子或类似物，R7是氢原子、可能具有取代基的杂环基团、C3-8环烷基团、可能具有取代基的氨基团或可能具有取代基的C1-6烷氧基团；M1是单键、C1-4烷基烃基团或类似物，Y是N或CRF（在该式中，RF代表氢原子、C1-6烷基基团或类似物），或其药学上可接受的盐，或其前药，或包含其的药物组合物和药物用途。

  公开号：

  EP1813603A1

文献信息

• Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both
  申请人：Yokoyama Kenji

  公开号：US20070232594A1

  公开（公告）日：2007-10-04

  A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and are represented by the general formula (I): wherein R 1 represents a hydrogen atom or a C 1-6 alkyl group which may have a substituent, R 2 is a hydrogen atom or a C 1-6 alkyl group, R 3 is a hydrogen atom, a C 1-6 alkyl group or the like, R 4 , R 5 and R 6 are independently a hydrogen atom, a halogen atom or the like, R 7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C 3-8 cycloalkyl group, an amino group which may have a substituent or a C 1-6 alkoxy group which may have a substituted group; M 1 is a single bond, a C 1-4 alkylene group or the like Y is N or CR F (in the formula, R F represents a hydrogen atom, a C 1-6 alkyl group or the like or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.

  本发明提供了具有V2受体激动作用的芳香酰胺衍生物，可用作治疗或预防尿崩症、夜尿症、夜间遗尿、过度活动膀胱等药物，其通式表示为（I）：其中R1表示氢原子或C1-6烷基，可以有取代基，R2表示氢原子或C1-6烷基，R3表示氢原子、C1-6烷基或类似物，R4、R5和R6分别表示氢原子、卤原子或类似物，R7表示氢原子、可以有取代基的杂环芳基、C3-8环烷基、可以有取代基的氨基或C1-6烷氧基；M1表示单键、C1-4烷基等，Y表示N或CRF（在公式中，RF表示氢原子、C1-6烷基或类似物的药物可接受的盐，或其前药，或包含它的制药组合物和制药用途）。
• AROMATIC AMIDE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME, MEDICAL USES OF BOTH
  申请人：Kissei Pharmaceutical Co., Ltd.

  公开号：EP1813603A1

  公开（公告）日：2007-08-01

  A present invention provides aromatic amide derivatives which have an agonism of V2 receptor, are useful as agents for the treatment or prevention of diabetes insipidus, nocturia, nocturnal enuresis, overactive bladder or the like, and are represented by the general formula (I): wherein R1 represents a hydrogen atom or a C1-6 alkyl group which may have a substituent, R2 is a hydrogen atom or a C1-6 alkyl group, R3 is a hydrogen atom, a C1-6 alkyl group or the like, R4, R5 and R6 are independently a hydrogen atom, a halogen atom or the like, R7 is a hydrogen atom, a heteroaryl group which may have a substituent, a C3-8 cycloalkyl group', an amino group which may have a substituent or a C1-6 alkoxy group which may have a substituted group; M1 is a single bond, a C1-4 alkylene group or the like Y is N or CRF (in the formula, RF represents a hydrogen atom, a C1-6 alkyl group or the like or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or pharmaceutical compositions comprising the same and pharmaceutical uses thereof.

  本发明提供了具有V2受体激动作用的芳香酰胺衍生物，可用作治疗或预防尿崩症、夜尿症、夜间遗尿、膀胱过度活跃或类似疾病的药物，并由通式（I）表示： 其中R1代表氢原子或可能具有取代基的C1-6烷基基团，R2是氢原子或C1-6烷基基团，R3是氢原子、C1-6烷基基团或类似物，R4、R5和R6独立地是氢原子、卤原子或类似物，R7是氢原子、可能具有取代基的杂环基团、C3-8环烷基团、可能具有取代基的氨基团或可能具有取代基的C1-6烷氧基团；M1是单键、C1-4烷基烃基团或类似物，Y是N或CRF（在该式中，RF代表氢原子、C1-6烷基基团或类似物），或其药学上可接受的盐，或其前药，或包含其的药物组合物和药物用途。