diisopropylamine | 1150097-15-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diisopropylamine
• CAS: 1150097-15-6
• 化学式: C₆H₁₄N₂O
• 分子量: 129.183
• InChiKey: AUIKJTGFPFLMFP-JZRMKITLSA-N

反应信息

• 作为产物：
  描述：

  triphenyl(diisopropylamin-1-yl)phosphonium bromide 在 [13N]NO2(1-) 作用下， 以 二氯甲烷 为溶剂， 生成 diisopropylamine
  参考文献：
  名称：

  Efficient system for the preparation of [13N]labeled nitrosamines

  摘要：

  In the present Letter, a fast and reproducible method for the synthesis of N-[N-13]nitrosamines is reported. The labeling strategy is based on trapping [N-13]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph3P and Br-2 led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.066

文献信息

• Synthesis of 13N-labelled radiotracers by using microfluidic technology
  作者：Vijay Gaja、Vanessa Gómez-Vallejo、Mar Cuadrado-Tejedor、José I. Borrell、Jordi Llop

  DOI：10.1002/jlcr.2946

  日期：2012.7

  Microfluidics has recently emerged as a useful alternative to traditional methods for the preparation of radiotracers labelled with positron emitters. Up to date, microfluidics technology has been applied to the radiosynthesis of 18F-labelled and 11C-labelled compounds; however, application to other shorter-lived positron emitters has not been investigated. The radiosynthesis of S-[13N]nitrosothiols and N-[13N]nitrosamines was approached in microfluidic system by reaction of the corresponding thiol or secondary amine, respectively, with [13N]NO2− in the presence of mineral acid. The radiosynthesis of azo compounds was carried out by reaction of the same labelling agent with primary aromatic amines in acidic media to yield the corresponding diazonium salts, which were further reacted with aromatic amines and alcohols to yield the corresponding 13N-labelled azo compounds. Radiochemical conversion values for S-[13N]nitrosothiols and 13N-labelled azo compounds calculated from chromatographic profiles improved our previous results by using conventional methods. The formation of N-[13N]nitrosamines could not be detected, independently of experimental conditions. In conclusion, the preparation of S-[13N]nitrosothiols and 13N-labelled azo compounds was successfully achieved by using microfluidics technology. Higher radiochemical conversions than those previously reported using conventional synthetic strategies have been obtained. Copyright © 2012 John Wiley & Sons, Ltd.

  微流控技术最近作为制备用正电子发射剂标记的放射性示踪剂的传统方法的有益替代品。迄今为止，微流控技术已应用于18F标记和11C标记化合物的放射合成；然而，对其他短寿命正电子发射剂的应用尚未进行研究。S-[13N]亚硝基硫醇和N-[13N]亚硝基胺的放射合成通过微流控系统实现，具体是对应的硫醇或二级胺与[13N]NO2−在矿物酸存在下反应。偶氮化合物的放射合成通过同样的标记试剂与酸性介质中的一级芳香胺反应，生成相应的联氮盐，这些联氮盐进一步与芳香胺和醇发生反应，生成相应的13N标记偶氮化合物。根据色谱分析得出的S-[13N]亚硝基硫醇和13N标记偶氮化合物的放射化学转化率值优于之前使用传统方法的结果。N-[13N]亚硝基胺的形成未能被检测，无论实验条件如何。总之，S-[13N]亚硝基硫醇和13N标记偶氮化合物的制备成功地通过微流控技术实现。获得的放射化学转化率高于之前使用传统合成策略所报告的结果。版权 © 2012 John Wiley & Sons, Ltd.