2,3-Bis[(4-cyanobenzoyl)oxy]butanedioic acid | 194225-25-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,3-Bis[(4-cyanobenzoyl)oxy]butanedioic acid
• CAS: 194225-25-7
• 化学式: C₂₀H₁₂N₂O₈
• 分子量: 408.3
• InChiKey: JPVQHICFDRDQQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  175
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• SYNTHESIS PROCESS OF RUXOLITINIB
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US20190023712A1

  公开（公告）日：2019-01-24

  The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

  本申请属于药物合成领域，具体地说，本申请涉及一种制备鲁索利替尼的方法，以及制备所用的中间体和相关中间体的方法。该方法包括将化合物II与化合物IV或其盐反应，得到化合物III，然后将化合物III进行酰卤化反应、酰胺化反应和去除酰胺脱水反应以形成氰基或去除保护基制备鲁索利替尼。该方法具有步骤简洁、立体选择性高、原子利用率高、反应条件温和、后处理方便的特点。该方法避免使用昂贵的不对称反应催化剂，适用于工业生产。
• Synthesis process of ruxolitinib
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

  公开号：US10562904B2

  公开（公告）日：2020-02-18

  The present application falls within the field of drug synthesis, and in particular, the present application relates to a method for preparing ruxolitinib, and a method for preparing the intermediate and relevant intermediates used. The method comprises reacting a compound of formula II with a compound of formula IV or a salt thereof to obtain a compound of formula III, and then subjecting the compound of formula III to an acyl halogenation reaction, an amidation reaction, and a reaction dehydrating an amide to form a cyano group or removing the protecting group to prepare ruxolitinib. The method has the characteristics of brief steps, a high stereoselectivity, a high utilization ratio of atoms, mild reaction conditions and convenient post treatment. The method avoids using expensive asymmetric reaction catalysts, and is suitable for industrial production.

  本申请属于药物合成领域，尤其是本申请涉及一种制备鲁索利替尼的方法，以及制备所用中间体和相关中间体的方法。该方法包括将式Ⅱ化合物与式Ⅳ化合物或其盐反应得到式Ⅲ化合物，然后将式Ⅲ化合物经酰基卤化反应、酰胺化反应和使酰胺脱水形成氰基或去除保护基的反应制备鲁索利替尼。该方法具有步骤简短、立体选择性高、原子利用率高、反应条件温和、后处理方便等特点。该方法避免了使用昂贵的不对称反应催化剂，适合工业化生产。
• Molecular controlled semiconductor device
  申请人：Cahen David

  公开号：US20060118903A1

  公开（公告）日：2006-06-08

  A semiconductor sensing device for sensing presence, absence or level of species-of-interest in the environment is disclosed. The semiconductor sensing device comprises at least one layer of molecules deposited thereon. The molecules are electrically-responsive to the species-of-interest in a manner such that when the molecules interact with the species-of-interest, a reverse breakdown voltage characterizing the semiconductor sensing device is modified.

  本发明公开了一种半导体传感装置，用于传感环境中是否存在感兴趣的物种或其含量。该半导体传感装置包括至少一层沉积在其上的分子。分子对相关物种具有电反应，当分子与相关物种相互作用时，半导体传感装置的反向击穿电压会发生变化。
• HYBRID ORGANIC-INORGANIC SEMICONDUCTOR STRUCTURES AND SENSORS BASED THEREON
  申请人：YEDA RESEARCH & DEVELOPMENT COMPANY, LTD.

  公开号：EP0935748A1

  公开（公告）日：1999-08-18
• EP1425411A4
  申请人：——

  公开号：EP1425411A4

  公开（公告）日：2004-06-23