An in situ phase change gel sustained-release preparation for a small molecule drug and a preparation method thereof. The in situ phase change gel sustained-release preparation comprises a small molecule drug comprising an active pharmaceutical ingredient, a phospholipid, Span, and an ethanol solution. The in situ phase change gel sustained-release preparation has a high concentration of phospholipids combined with Span, and is thus able to reduce the immediate-release of the small molecule drug and extend the release time, and is suitable for various administration routes, such as subcutaneous injection and external administration.
                            一种小分子药物原位相变凝胶缓释制剂及其制备方法。该原位相变凝胶缓释制剂由一种小分子药物(包括一种活性药物成分、一种
磷脂、司盘和一种
乙醇溶液)组成。该原位相变凝胶缓释制剂具有高浓度的
磷脂和斯盘,因此能够降低小分子药物的速释性并延长释放时间,适用于皮下注射和体外给药等多种给药途径。