2-methylene-malonic acid tert-butyl ester ethyl ester | 116861-35-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-methylene-malonic acid tert-butyl ester ethyl ester
• 英文别名: methylenemalonic acid tert-butyl ethyl ester；Methylenemalonic acid ethyl tert-butyl ester；3-O-tert-butyl 1-O-ethyl 2-methylidenepropanedioate
• CAS: 116861-35-9
• 化学式: C₁₀H₁₆O₄
• 分子量: 200.235
• InChiKey: MXEZPCPNBQZOKP-UHFFFAOYSA-N

物化性质

• 沸点：
  79-84 °C(Press: 0.5 Torr)
• 密度：
  1.024±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methylene-malonic acid tert-butyl ester ethyl ester 在 六甲基二硅氮烷 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-malonic acid monoethyl ester
  参考文献：
  名称：

  Active Methylene Phosphinic Peptides:  A New Diversification Approach

  摘要：

  Simple, rapid, and efficient methods for P-1' diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.

  DOI：

  10.1021/ol060575m
• 作为产物：
  描述：

  聚合甲醛 、 丙二酸叔丁基乙酯 在 copper diacetate 溶剂黄146 作用下， 反应 3.0h， 以52%的产率得到2-methylene-malonic acid tert-butyl ester ethyl ester
  参考文献：
  名称：

  Active Methylene Phosphinic Peptides:  A New Diversification Approach

  摘要：

  Simple, rapid, and efficient methods for P-1' diversification of phosphinic peptides have been developed, employing alkylation and Knoevenagel-type condensation reactions with active methylene phosphinic scaffolds, thus leading to a wide variety of diversified phosphinic and dehydrophosphinic peptides.

  DOI：

  10.1021/ol060575m

文献信息

• [EN] SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF<br/>[FR] SYNTHESE DES ACIDES 2-ALKYLCYSTEINES, 2-(PHENYLE HYDROXYLE)-4-ALKYLTHIAZOLINE-4-CARBOXYLIQUES ET DE LEURS DERIVES
  申请人：GENZYME CORP

  公开号：WO2003097622A2

  公开（公告）日：2003-11-27

  The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. An example of these iron chelating agents are 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-alkyl-thiazole-4-carboxylic acids, such as 4,5-dihydro-2-(2,4-dihydroxyphenyl)-4-methyl-thiazole-4-carboxylic acid.

  本发明提供了制备2-烷基半胱氨酸衍生物的方法，其中许多可以进行立体选择性。本发明还披露了一种制备与去铁蒺藜菌素相关的一类铁螯合剂的方法，所有这些铁螯合剂都含有噻唑环。这些铁螯合剂的一个例子是4,5-二氢-2-(2,4-二羟基苯基)-4-烷基噻唑-4-羧酸，例如4,5-二氢-2-(2,4-二羟基苯基)-4-甲基噻唑-4-羧酸。
• Malonic acid derivatives and methods for their synthesis
  申请人：Eniricerche S.p.A.

  公开号：US04914226A1

  公开（公告）日：1990-04-03

  The present invention refers to a new class of malonic acid derivatives of general formula I ##STR1## wherein R.sup.1 and R.sup.2, each independently, represent hydrogen or a carboxyl protecting group, and the residue R corresponds to the side-chain of the amino acids lysine, ornithine, tyrosine, cysteine, asparatic acid and glutamic acid wherein the additional functionalities are suitably protected. The new compounds of the present invention are useful for preparing analogues of biologically active peptides wherein the direction of some amide bonds in which the amino acids lysine, ornithine, tyrosine, cysteine, aspartic acid or glutamic acid are involved, has been reversed.

  本发明涉及一种新的马来酸衍生物类别，其一般式为I式：##STR1##其中，R.sup.1和R.sup.2各自独立地代表氢或羧基保护基，残基R对应于氨基酸赖氨酸、鸟氨酸、酪氨酸、半胱氨酸、天冬酰氨酸和谷氨酸的侧链，其中附加的官能团适当地保护。本发明的新化合物可用于制备生物活性肽的类似物，其中氨基酸赖氨酸、鸟氨酸、酪氨酸、半胱氨酸、天冬酰氨酸或谷氨酸所涉及的一些酰胺键的方向已被反转。
• Synthesis of 2-alkyl amino acids
  申请人：Chorghade S. Mukund

  公开号：US20060167267A1

  公开（公告）日：2006-07-27

  Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

  非天然氨基酸，如2-烷基化氨基酸，可以合成更多种类的肽类和非肽类药物。制备2-烷基氨基酸的方法涉及将亲核试剂进行Michael型加成反应到二烷基2-甲基亚乙烯基丙酸-1,3-二酯上，并将酯基转化为氨基基团。本发明还揭示了一种制备与去铁血霉素相关的一类含有噻唑环的铁螯合剂的方法。在该方法中，芳基腈或咪唑酯与半胱氨酸、2-烷基半胱氨酸或半胱氨酸酯缩合。
• FOAMED PRODUCT IN A SHEET FORM AND METHOD FOR PRODUCTION THEREOF
  申请人：OJI PAPER CO., LTD.

  公开号：EP1647570A1

  公开（公告）日：2006-04-19

  The present invention discloses a foam sheet and its production process comprising the formation of a plurality of independent cells and/or a plurality of continuous cells. The foam sheet is produced from a foamable composition that contains an acid generator that generates an acid or a base generator that generates a base due to the action of an active energy beam and a compound that has a decomposing foamable functional group that decomposes and eliminates one or more types of low boiling point volatile substances by reacting with the acid or base.

  本发明公开了一种泡沫板及其生产工艺，包括形成多个独立单元和/或多个连续单元。泡沫板由一种可发泡组合物生产而成，该组合物含有一种酸发生器（在活性能量束的作用下产生一种酸）或一种碱发生器（在活性能量束的作用下产生一种碱），以及一种化合物，该化合物具有一种可分解泡沫的官能团，通过与酸或碱反应，分解并消除一种或多种低沸点挥发性物质。
• Foamed product in a sheet form and method for production thereof
  申请人：Takada Tomoyuki

  公开号：US20060210785A1

  公开（公告）日：2006-09-21

  The present invention discloses a foam sheet and its production process comprising the formation of a plurality of independent cells and/or a plurality of continuous cells. The foam sheet is produced from a foamable composition that contains an acid generator that generates an acid or a base generator that generates a base due to the action of an active energy beam and a compound that has a decomposing foarmable functional group that decomposes and eliminates one or more types of low boiling point volatile substances by reacting with the acid or base.

  本发明公开了一种泡沫板及其生产工艺，包括形成多个独立单元和/或多个连续单元。泡沫板由一种可发泡组合物生产而成，该组合物含有一种酸发生器（在活性能量束的作用下产生一种酸）或一种碱发生器（在活性能量束的作用下产生一种碱），以及一种化合物，该化合物具有一种可分解泡沫的官能团，通过与酸或碱反应，分解并消除一种或多种低沸点挥发性物质。