methyl 4-[1-(4-bromophenyl)-6,6-dimethyl-4-oxo-2-phenyl-4,5,6,7-tetrahydro-1H-indol-7-yl]-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate | 1446254-42-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: methyl 4-[1-(4-bromophenyl)-6,6-dimethyl-4-oxo-2-phenyl-4,5,6,7-tetrahydro-1H-indol-7-yl]-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
• CAS: 1446254-42-7
• 化学式: C₃₃H₂₈BrN₃O₄
• 分子量: 610.507
• InChiKey: IKXDPDCTTJSRCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.33
• 重原子数：
  41.0
• 可旋转键数：
  5.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  86.35
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  methyl 5-hydroxyl-1-phenyl-1H-pyrazole-3-carboxylate 、 1-(4-bromophenyl)-4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-2-phenyl-1H-indolindol-7-yl acetate 在 溶剂黄146 作用下， 以82%的产率得到methyl 4-[1-(4-bromophenyl)-6,6-dimethyl-4-oxo-2-phenyl-4,5,6,7-tetrahydro-1H-indol-7-yl]-5-hydroxy-1-phenyl-1H-pyrazole-3-carboxylate
  参考文献：
  名称：

  A novel allylic substitution strategy to four-component synthesis of pyrazole-substituted fused pyrroles

  摘要：

  The selective formation of pyrazole-substituted fused pyrroles through HOAc-mediated multicomponent reactions of enaminones with arylglyoxal monohydrates and generated in situ pyrazole-3-carboxylates was developed. It constructed a variety of bis-heterocyclic pairs under mild conditions in a domino process. Reaction driving tandem cyclization/allylic esterification/allylic substitution was achieved through the formation of in situ generation of allyl esters and pyrazole-3-carboxylates from readily available starting materials. Up to two new five-membered heterocyclic rings and five new sigma bonds including a C(sp3)-C(sp2) bond were formed in a single reaction without isolated intermediates. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.05.063