6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxylic acid | 1297546-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxylic acid
• 英文别名: 4H,6H,7H-pyrano[3,4-d][1,2]oxazole-3-carboxylic acid；6,7-dihydro-4H-pyrano[3,4-d][1,2]oxazole-3-carboxylic acid
• CAS: 1297546-74-7
• 化学式: C₇H₇NO₄
• 分子量: 169.137
• InChiKey: KYLRPSOCSSHQKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxylic acid 、 3-(5-amino-2-methylpyridin-3-yl)-N-methyl-1,6-naphthyridin-7-amine 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以38%的产率得到N-(6-methyl-5-(7-(methylamino)-1,6-naphthyridin-3-yl)pyridin-3-yl)-6,7-dihydro-4H-pyrano[3,4-d]isoxazole-3-carboxamide
  参考文献：
  名称：

  [EN] 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES
  [FR] DÉRIVÉS DE 6-AZA-QUINOLÉINE ET UTILISATIONS ASSOCIÉES

  摘要：

  The present disclosure relates compounds of Formula (0): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in the treatment of cancer.

  公开号：

  WO2023039505A1

文献信息

• ANDROGEN RECEPTOR MODULATING COMPOUNDS
  申请人：Wohlfahrt Gerd

  公开号：US20120225867A1

  公开（公告）日：2012-09-06

  The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.

  本公开涉及式(I)的化合物及其药学上可接受的盐。本公开还涉及包括式(I)的化合物及其药学上可接受的盐的组合物和治疗方法。
• Androgen receptor modulating compounds
  申请人：Wohlfahrt Gerd

  公开号：US08975254B2

  公开（公告）日：2015-03-10

  The present disclosure relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The present disclosure also relates to compositions and methods of treating comprising compounds of formula (I), and pharmaceutically acceptable salts thereof.

  本公开涉及式(I)的化合物及其药学上可接受的盐。本公开还涉及包含式(I)的化合物及其药学上可接受的盐的组合物和治疗方法。
• US8975254B2
  申请人：——

  公开号：US8975254B2

  公开（公告）日：2015-03-10
• US9657003B2
  申请人：——

  公开号：US9657003B2

  公开（公告）日：2017-05-23
• [EN] ANDROGEN RECEPTOR MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULATEURS DE RÉCEPTEURS DES ANDROGÈNES
  申请人：ORION CORP

  公开号：WO2011051540A1

  公开（公告）日：2011-05-05

  Compounds of formula (I) wherein R1 to R16, A. B and E are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective androgen receptor modulators (SARM) and are particularly useful as medicaments in the treatment of prostate cancer and other AR dependent conditions and diseases where AR antagonism is desired.