2-[[4-Methoxy-3-[2-(2-methylphenyl)ethoxy]benzoyl]amino]-1,3-dihydroindene-2-carboxylic acid | 1195942-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[[4-Methoxy-3-[2-(2-methylphenyl)ethoxy]benzoyl]amino]-1,3-dihydroindene-2-carboxylic acid
• CAS: 1195942-55-2
• 化学式: C₂₇H₂₇NO₅
• 分子量: 445.515
• InChiKey: SSJVQFYNNLYZTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• CRYSTALLINE EDG-2 RECEPTOR ANTAGONIST AND METHODS OF MAKING
  申请人：Sanofi

  公开号：US20220064105A1

  公开（公告）日：2022-03-03

  Described herein are crystalline forms of 2-(4-methoxy-3-(3-methylphenethoxy)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid and methods of making the same. Such forms of 2-(4-methoxy-3-(3-methylphenethoxy)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid are useful in the preparation of pharmaceutical compositions for the treatment of diseases or conditions that would benefit by administration with an EDG-2 receptor antagonist compound.
• [EN] CRYSTALLINE EDG-2 RECEPTOR ANTAGONIST AND METHODS OF MAKING<br/>[FR] ANTAGONISTE DU RÉCEPTEUR EDG-2 CRISTALLIN ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
  申请人：[en]SANOFI

  公开号：WO2022043755A2

  公开（公告）日：2022-03-03

  Described herein are crystalline forms of 2-(4-methoxy-3-(3-methylphenethoxy)benzamido)-2,3- dihydro-1H-indene-2-carboxylic acid and methods of makingthe same. Such forms of 2-(4- methoxy-3-(3-methylphenethoxy)benzamido)-2,3-dihydro-1H-indene-2-carboxylic acid are useful in the preparation of pharmaceutical compositions for the treatment of diseases or conditions that would benefit by administration with an EDG-2 receptor antagonist compound.