N-(2-hydroxyethyl)-N-prop-2-enylacetamide | 40705-46-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-hydroxyethyl)-N-prop-2-enylacetamide
• CAS: 40705-46-2
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: QEXIQWARTHBMIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(2-hydroxyethyl)-N-prop-2-enylacetamide 在 双(乙腈)氯化钯(II) 、 氧气 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以75%的产率得到4-acetyl-6-methyl-3,4-dihydro-2H-1,4-oxazine
  参考文献：
  名称：

  Intramolecular Oxidative Pd(II)-Catalyzed Alkoxylation of 3-Aza-5-alkenols with O2 as Sole Oxidant: Mild Conditions for the Synthesis of 1,4-Oxazine Derivatives

  摘要：

  1,4-2H-吡嗪衍生物的合成是通过Pd(II)催化的有氧氧化环化反应实现的，该反应使用了由易得的1,2-氨基醇制备的3-氮-5-烯醇。在极温和的条件下，该反应在室温下以THF中的PdCl2(MeCN)2作为简单的催化系统，分子氧作为唯一的计量氧化剂进行。

  DOI：

  10.1055/s-0030-1259295
• 作为产物：
  描述：

  N-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-N-prop-2-enylacetamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以94%的产率得到N-(2-hydroxyethyl)-N-prop-2-enylacetamide
  参考文献：
  名称：

  Intramolecular Oxidative Pd(II)-Catalyzed Alkoxylation of 3-Aza-5-alkenols with O2 as Sole Oxidant: Mild Conditions for the Synthesis of 1,4-Oxazine Derivatives

  摘要：

  1,4-2H-吡嗪衍生物的合成是通过Pd(II)催化的有氧氧化环化反应实现的，该反应使用了由易得的1,2-氨基醇制备的3-氮-5-烯醇。在极温和的条件下，该反应在室温下以THF中的PdCl2(MeCN)2作为简单的催化系统，分子氧作为唯一的计量氧化剂进行。

  DOI：

  10.1055/s-0030-1259295

文献信息

• AMPHIPHILIC SILOXANE-CONTAINING VINYLIC MONOMERS AND USES THEREOF
  申请人：Novartis AG

  公开号：US20140171542A1

  公开（公告）日：2014-06-19

  The invention provides an amphiphilic siloxane-containing vinylic monomer which comprises one sole ethylenically unsaturated group and a siloxane-containing group covalently linked to the ethylenically-unsaturated group through a hydrophilic linker. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from an amphiphilic siloxane-containing vinylic monomer of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an amphiphilic siloxane-containing vinylic monomer of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
• ACTINICALLY-CROSSLINKABLE AMPHIPHILIC PREPOLYMERS
  申请人：Novartis AG

  公开号：US20140171543A1

  公开（公告）日：2014-06-19

  The invention provide a class of actinically-crosslinkable amphiphilic prepolymers which comprise at least one polysiloxane segment, at least one polyoxazoline segment, and two terminal ene groups. The present invention is also related to a medical device comprising a silicone hydrogel material obtained from step-growth polymerization of a polymerizable material comprising a prepolymer of the invention and to a method for producing contact lenses from a prepolymer of the invention.
• POLYMERIZABLE POLYSILOXANES WITH HYDROPHILIC SUBSTITUENTS
  申请人：Novartis AG

  公开号：US20160090432A1

  公开（公告）日：2016-03-31

  The invention provides an actinically-polymerizable amphiphilic polysiloxane which comprises a polysiloxane polymer chain comprising a polylsiloxane segments comprising at least one siloxane unit having a low molecular weight hydrophilic polymer chain connected with a silicone atom of the siloxane unit, and (meth)acrylamido groups each covalently bonded to one of the ends of the polysiloxane polymer chain and/or to the end of one of low molecular weight hydrophilic polymer chains each connected with one silicone atom. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises repeating units derived from an actinically-polymerizable amphiphilic polysiloxane of the invention. In addition, the invention provides a method for making silicone hydrogel contact lenses using a water-based lens-forming formulation comprising an actinically-polymerizable amphiphilic polysiloxane of the invention and/or an actinically-crosslinkable silicone-containing prepolymer of the invention.
• US9103965B2
  申请人：——

  公开号：US9103965B2

  公开（公告）日：2015-08-11
• US9151873B2
  申请人：——

  公开号：US9151873B2

  公开（公告）日：2015-10-06