3-(4-pyridin-3-yl-1H-imidazol-1-yl)propan-1-amine | 325478-13-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(4-pyridin-3-yl-1H-imidazol-1-yl)propan-1-amine
• 英文别名: 3-[4-(pyridin-3-yl)-1H-imidazol-l-yl]propan-1-amine；3-(4-Pyridin-3-ylimidazol-1-yl)propan-1-amine
• CAS: 325478-13-5
• 化学式: C₁₁H₁₄N₄
• 分子量: 202.259
• InChiKey: RDQSYTCPUQDOSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  56.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-pyridin-3-yl-1H-imidazol-1-yl)propan-1-amine 在 甲酸 、 草酰氯 、 碘代三甲硅烷 、 N,N-二甲基甲酰胺 作用下， 以 甲醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 反应 8.42h， 生成
  参考文献：
  名称：

  A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2)

  摘要：

  A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether and its analogues were prepared, and their antibacterial activities and pharmacokinetic properties were evaluated. We found that the introduction of all (R)-alkyl group between the amide and iminoether groups could improve the pharmacokinetic properties while maintaining the activity against erythromycin-resistant Streptococcus pneumoniae. Among the ketolides prepared with the (R)-alkyl group, compound 5p with an N-(3-quinoxalin-6-yl-propyl)-propionamide moiety was found to have in vivo efficacy comparable to CAM with potent in vitro antibacterial activities against the key respiratory pathogens including Haemophilus influenzae and erythromycin-resistant S. pneumoniae. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.01.036
• 作为产物：
  描述：

  2-[3-(4-Pyridin-3-yl-imidazol-1-yl)-propyl]-isoindole-1,3-dione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 3-(4-pyridin-3-yl-1H-imidazol-1-yl)propan-1-amine
  参考文献：
  名称：

  A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2)

  摘要：

  A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether and its analogues were prepared, and their antibacterial activities and pharmacokinetic properties were evaluated. We found that the introduction of all (R)-alkyl group between the amide and iminoether groups could improve the pharmacokinetic properties while maintaining the activity against erythromycin-resistant Streptococcus pneumoniae. Among the ketolides prepared with the (R)-alkyl group, compound 5p with an N-(3-quinoxalin-6-yl-propyl)-propionamide moiety was found to have in vivo efficacy comparable to CAM with potent in vitro antibacterial activities against the key respiratory pathogens including Haemophilus influenzae and erythromycin-resistant S. pneumoniae. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.01.036

文献信息

• 10A-AZALIDE COMPOUND HAVING 4-MEMBERED RING STRUCTURE
  申请人：Sugimoto Tomohiro

  公开号：US20110152239A1

  公开（公告）日：2011-06-23

  The present invention relates to a process for preparing compositions of high concentrations of omega-3 fatty acids from krill. Furthermore, the invention relates to a composition comprising high concentrations of omega-3 fatty acids, and a lipid fraction from krill comprising high amounts of the fatty acids with chain length C14 and C 16.

  本发明涉及一种从磷虾制备高浓度ω-3脂肪酸组合物的方法。此外，本发明涉及一种包含高浓度ω-3脂肪酸的组合物，以及从磷虾中提取的含有链长为C14和C16的脂肪酸高含量的脂质分数。
• 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS
  申请人：Sugimoto Tomohiro

  公开号：US20110237784A1

  公开（公告）日：2011-09-29

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，并且对于Hemophilus influenzae，或者对红霉素产生耐药性的细菌（例如耐药性肺炎球菌和链球菌）具有有效性。
• 10A-AZALIDE COMPOUND CROSSLINKED AT POSITION-10A AND POSITION-12
  申请人：Taisho Pharmaceutical Co. Ltd.

  公开号：EP2177526A1

  公开（公告）日：2010-04-21

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae, or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种在 10a- 位和 12- 位交联的新型 10a- 叠氮酰胺化合物，由下式表示，甚至对流感嗜血杆菌或红霉素耐药菌（如耐药肺炎球菌和链球菌）也有效。
• EP2177526
  申请人：——

  公开号：——

  公开（公告）日：——
• US8293715B2
  申请人：——

  公开号：US8293715B2

  公开（公告）日：2012-10-23