(S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine | 214753-58-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine
• CAS: 214753-58-9
• 化学式: C₄₀H₄₆N₂O₆Si
• 分子量: 678.901
• InChiKey: ZOELZKCAOIEOSD-BHVANESWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.23
• 重原子数：
  49.0
• 可旋转键数：
  15.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  113.96
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine 在 四丁基氟化铵 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 9.0h， 生成 (2R,4S)-2-hydroxymethyl-4-[(S)-N-(6-aminohexanoyl)serylamino]-6-methyl-1,2-oxiranylheptane
  参考文献：
  名称：

  Eponemycin analogues: syntheses and use as probes of angiogenesis

  摘要：

  Derivatives of the epoxy-beta-aminoketone containing natural product eponemycin have been prepared in order to study the molecular mode of action of this anti-angiogenic compound. Synthesis and use of a biotinylated dihydroeponemycin analogue demonstrated that dihydroeponemycin forms a covalent adduct with at least two intracellular proteins in human endothelial cells. Pretreatment of cells with a five equivalent excess of dihydroeponemycin precluded biotin-dihydroeponemycin binding indicating a specific interaction between natural product and the target proteins. This biotin-dihydroeponemycin derivative will prove useful in the purification and identification of eponemycin receptors. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00089-3
• 作为产物：
  描述：

  (S)-N-[6-(N-fluorenylmethoxycarbonylamino)hexanoyl]serine benzyl ester 在 palladium on activated charcoal 咪唑 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 16.25h， 生成 (S)-[O-tertbutyldiphenylsiloxymethyl-N-(6-N-fluorenylmethoxycarbonylamino)hexanoyl]serine
  参考文献：
  名称：

  Eponemycin analogues: syntheses and use as probes of angiogenesis

  摘要：

  Derivatives of the epoxy-beta-aminoketone containing natural product eponemycin have been prepared in order to study the molecular mode of action of this anti-angiogenic compound. Synthesis and use of a biotinylated dihydroeponemycin analogue demonstrated that dihydroeponemycin forms a covalent adduct with at least two intracellular proteins in human endothelial cells. Pretreatment of cells with a five equivalent excess of dihydroeponemycin precluded biotin-dihydroeponemycin binding indicating a specific interaction between natural product and the target proteins. This biotin-dihydroeponemycin derivative will prove useful in the purification and identification of eponemycin receptors. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00089-3