| 1191919-19-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1191919-19-3
• 化学式: C₁₂H₁₀Cl₂N₂O₂
• 分子量: 285.13
• InChiKey: XYCWDMJBFMJFCR-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  哌嗪 、 以 乙醇 为溶剂， 生成 2-((3-chlorophenoxy)methyl)-3-methyl-6-(piperazin-1-yl)pyrimidin-4(3H)-one
  参考文献：
  名称：

  Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT2C agonists

  摘要：

  This Letter reports the design and synthesis of several novel series of piperazinyl pyrimidinones as 5-HT2C agonists. Several of the compounds presented exhibit good in vitro potency and selectivity over the closely related 5-HT2A and 5-HT2B receptors. Compound 11 was active in in vivo models of stress urinary incontinence. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.07.133