3-硝基-5-甲基咪唑并[1,2-a]吡啶 | 34165-08-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 中文名称: 3-硝基-5-甲基咪唑并[1,2-a]吡啶
• 中文别名: 3-硝基-5-甲基咪唑并[1,2-A]吡啶；5-甲基-3-硝基咪唑并[1,2-a]吡啶
• 英文名称: 5-methyl-3-nitroimidazo[1,2-a]pyridine
• CAS: 34165-08-7
• 化学式: C₈H₇N₃O₂
• 分子量: 177.162
• InChiKey: OGZKKWYLIWRTHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.1
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  3-硝基-5-甲基咪唑并[1,2-a]吡啶 在 N-氯代丁二酰亚胺 作用下， 以 四氢呋喃 为溶剂， 以41%的产率得到3-Chloro-5-chloromethyl-imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position

  摘要：

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.

  DOI：

  10.3987/com-00-9063
• 作为产物：
  描述：

  5-甲基咪唑并[1,2-a]吡啶 在 硫酸 、 硝酸 作用下， 反应 5.0h， 以62%的产率得到3-硝基-5-甲基咪唑并[1,2-a]吡啶
  参考文献：
  名称：

  Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position

  摘要：

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.

  DOI：

  10.3987/com-00-9063

文献信息

• HAND E. S.; PAUDLER W. W., J. ORG. CHEM., 1978, 43, NO 14, 2900-2906
  作者：HAND E. S.、 PAUDLER W. W.

  DOI：——

  日期：——
• Reactions with N-Chlorosuccinimide of Various 5-Methylimidazo[1,2-a]pyridine Derivatives with an Electron-withdrawing Group Substituted at the 3-Position
  作者：Tomomi Ikemoto、Mitsuhiro Wakimasu

  DOI：10.3987/com-00-9063

  日期：——

  Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.