4-Methyl-4-ethyl-decancarbonsaeure | 53380-16-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Methyl-4-ethyl-decancarbonsaeure
• 英文别名: 4-Ethyl-4-methyldecanoic acid
• CAS: 53380-16-8
• 化学式: C₁₃H₂₆O₂
• 分子量: 214.348
• InChiKey: WHXXPWUZIZTEAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-Ethyl-4-decanolide 、 甲基二氯化铝 生成 4-Methyl-4-ethyl-decancarbonsaeure
  参考文献：
  名称：

  Reinheckel,H. et al., Journal fur praktische Chemie (Leipzig 1954), 1974, vol. 316, # 2, p. 215 - 222

  摘要：

  DOI：

文献信息

• Cyclosporin derivatives and uses thereof
  申请人：S&T Global Inc.

  公开号：US10647747B2

  公开（公告）日：2020-05-12

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.

  本发明涉及一种式 (I)) 的化合物： 或其药学上可接受的盐，其中符号如说明书中所定义；包含该化合物的药物组合物；治疗或预防病毒感染、炎症、干眼症、中枢神经紊乱、心血管疾病、癌症、肥胖症、糖尿病、肌肉萎缩症和脱发的方法。
• Substituted pyrimidines containing acidic groups as TLR7 modulators
  申请人：Apros Therapeutics, Inc.

  公开号：US10786502B2

  公开（公告）日：2020-09-29

  The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers. One aspect of the present disclosure relates to a compound represented by Formula 1:

  本公开涉及一类具有免疫调节特性的嘧啶衍生物，它们通过 TLR7 起作用，可用于治疗病毒感染和癌症。本公开的一个方面涉及由式 1 表示的化合物：
• NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF
  申请人：S&T Global Inc.

  公开号：US20180105558A1

  公开（公告）日：2018-04-19

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.
• PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS
  申请人：Apros Therapeutics, Inc.

  公开号：US20190314372A1

  公开（公告）日：2019-10-17

  The present disclosure relates to a class of pyrimidine derivatives having immunomodulating properties that act via TLR7 which are useful in the treatment of viral infections and cancers.
• US9890198B2
  申请人：——

  公开号：US9890198B2

  公开（公告）日：2018-02-13