1-iodo-2-(methoxymethoxy)-5-methylbenzene | 111636-03-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-iodo-2-(methoxymethoxy)-5-methylbenzene
• 英文别名: 2-Iodo-1-(methoxymethoxy)-4-methylbenzene
• CAS: 111636-03-4
• 化学式: C₉H₁₁IO₂
• 分子量: 278.09
• InChiKey: KQEKJVCFFUZXGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-iodo-2-(methoxymethoxy)-5-methylbenzene 在 盐酸 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 potassium carbonate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 2.0h， 生成 5-methyl-2-(4-methylphenyl)benzofuran
  参考文献：
  名称：

  Highly efficient heterogeneous synthesis of benzofurans under aqueous condition

  摘要：

  Highly efficient organic reactions in water are important for designing environmental-friendly and low cost synthetic processes. Herein, we demonstrate an intermediate-in-water strategy for the heterogeneous synthesis of benzofurans in aqueous media. The cyclization reaction of 2-(phenylethynyl)phenol to 2-phenylbenzofuran cannot proceed in pure water. However, this reaction can be efficiently promoted by the formation of sparingly soluble intermediate in the presence of alkaline. Quantitative conversion of a variety of substrates to benzofuran derivatives has been achieved in the absence of noble metal catalyst. Other remarkable features including easy-isolation and purification of product, along with wide range of functional group tolerance render the methodology promising in the realm of green-synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.04.005
• 作为产物：
  描述：

  1-甲氧基甲氧基-4-甲基苯; 4-(甲氧基甲氧基)甲苯 在 碘 、 lithium 作用下， 生成 1-iodo-2-(methoxymethoxy)-5-methylbenzene
  参考文献：
  名称：

  酯类均烯酸锌的碳-碳键形成反应。一种具有通用合成效用的新型三碳亲核试剂

  摘要：

  反应 d'addition sur les 组成羰基、烯丙基化、芳基化、乙烯基化和酰化在非脱催化剂的存在下

  DOI：

  10.1021/ja00260a018

文献信息

• Spontaneous Helix Formation of “<i>meta</i>”-Ethynylphenol Oligomers by Sequential Intramolecular Hydrogen Bonding inside the Cavities
  作者：Tomoya Hayashi、Yuki Ohishi、So Hee-Soo、Hajime Abe、Shinya Matsumoto、Masahiko Inouye

  DOI：10.1021/acs.joc.8b00996

  日期：2018.8.3

  architecturally simple oligomers spontaneously formed helical higher-order structures by sequential intramolecular hydrogen bonds through the multiple phenolic hydroxy groups inside the cavities. The hydrogen bonds forced C–C≡C–C bond angles to largely bend toward the inside. Addition of chiral amines caused the helices to be chiral by electrostatic interactions between the resulting chiral ammonium cations

  在他们与炔联苯酚低聚物元位置，“元” -ethynylphenol低聚物，被开发作为合成螺旋foldamer。结构上简单的低聚物通过腔内的多个酚羟基通过连续的分子内氢键自发形成螺旋高阶结构。氢键迫使C–C≡C–C键角向内弯曲。手性胺的添加通过所得到的手性铵阳离子与酚酸根阴离子之间的静电相互作用使螺旋成为手性。
• NAKAMURA, EIICHI;AOKI, SATOSHI;SEKIYA, KOUICHI;OSHINO, HIROJI;KUWAJIMA, I+, J. AMER. CHEM. SOC., 109,(1987) N 26, 8056-8066
  作者：NAKAMURA, EIICHI、AOKI, SATOSHI、SEKIYA, KOUICHI、OSHINO, HIROJI、KUWAJIMA, I+

  DOI：——

  日期：——
• [EN] NOVEL CYCLOPENTA[B]THIOPHENYL TRANSITION METAL COMPOUND, TRANSITION METAL CATALYST COMPOSITION COMPRISING SAME, AND METHOD FOR PREPARING ETHYLENE HOMOPOLYMERS OR COPOLYMERS OF ETHYLENE AND α-OLEFINS USING SAME<br/>[FR] NOUVEAU COMPOSÉ À BASE DE MÉTAL DE TRANSITION DE CYCLOPENTA[B]THIOPHÉNYL, COMPOSITION DE CATALYSEUR À BASE DE MÉTAL DE TRANSITION, PROCÉDÉ DE PRÉPARATION D'HOMOPOLYMÈRES OU DE COPOLYMÈRES D'ÉTHYLÈNE ET DE α-OLÉFINES L'UTILISANT<br/>[KO] 신규한 시클로펜타[Ｂ]티오펜일 전이금속 화합물, 이를 포함하는 전이금속 촉매 조성물, 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법
  申请人：SABIC SK NEXLENE COMPANY PTE LTD

  公开号：WO2018122693A1

  公开（公告）日：2018-07-05

  본 발명은 시클로펜타[b]티오펜일(cyclopenta[b]thiophenyl)기에 기초한 신규 전이금속 화합물, 이를 포함하는 에틸렌 단독중합체 또는 에틸렌과 하나 이상의 α-올레핀의 공중합체 제조용으로 높은 촉매활성을 가진 전이금속 촉매 조성물 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법에 관한 것이다.
• [EN] NOVEL INDENE-BASED TRANSITION METAL COMPOUND, CATALYST COMPOSITION CONTAINING SAME, AND METHOD FOR PREPARING ETHYLENE HOMOPOLYMER OR COPOLYMER OF ETHYLENE AND α-OLEFIN BY USING SAME<br/>[FR] NOUVEAU COMPOSÉ DE MÉTAL DE TRANSITION À BASE D'INDÈNE, COMPOSITION DE CATALYSEUR LE CONTENANT, ET PROCÉDÉ DE PRÉPARATION D'HOMOPOLYMÈRE OU DE COPOLYMÈRE D'ÉTHYLÈNE ET D'UNE ALPHA-OLÉFINE EN UTILISANT CETTE COMPOSITION<br/>[KO] 신규한 인덴계 전이금속 화합물, 이를 포함하는 촉매 조성물, 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법
  申请人：SABIC SK NEXLENE COMPANY PTE LTD

  公开号：WO2018127795A1

  公开（公告）日：2018-07-12

  본 발명은 신규한 인덴계 전이금속 화합물, 이를 포함하는 에틸렌 단독중합체 또는 에틸렌과 하나 이상의 α-올레핀의 공중합체 제조용으로 높은 촉매활성을 가진 전이금속 촉매 조성물 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법에 관한 것이다.