4-(2-chloro-4-formylphenoxy)butanoic acid | 174884-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-(2-chloro-4-formylphenoxy)butanoic acid
• CAS: 174884-36-7
• 化学式: C₁₁H₁₁ClO₄
• 分子量: 242.659
• InChiKey: ZAQGUGMNKZJMRN-UHFFFAOYSA-N

物化性质

• 沸点：
  456.0±35.0 °C(Predicted)
• 密度：
  1.339±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(2-氯-4-甲酰基苯氧基)丁酸乙酯 生成 4-(2-chloro-4-formylphenoxy)butanoic acid 、 4-(4-乙酰基-苯氧基)-丁酸
  参考文献：
  名称：

  Enediyne derivatives useful for the synthesis of conjugates of

  摘要：

  这项发明描述了从强效抗肿瘤抗生素calicheamicin家族的二硫化物类似物及其衍生物以及类似的来自于相关抗肿瘤抗生素esperamicin的类似物制备的载体-药物共轭物，载体可以是针对不需要的细胞群体（例如肿瘤细胞）的抗体、生长因子或类固醇。整个蛋白质载体以及它们的抗原识别片段和其化学或基因组操作的对应物都可用于共轭物的靶向部分。该发明包括合成这些共轭物所需的化合物、适当的药物组合物和它们的使用方法。

  公开号：

  US05739116A1

文献信息

• Conjugates of methyltrithio antitumor agents and intermediates for their
  申请人：American Cyanamid Company

  公开号：US05773001A1

  公开（公告）日：1998-06-30

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由卡利奇阿霉素家族的二硫化物类似物及其衍生物制备的载体-药物共轭物，以及来自相关抗肿瘤抗生素（如埃斯佩拉霉素）的类似物。载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，如肿瘤细胞。整个蛋白质载体以及其抗原识别片段和其化学或基因操作的对应物对共轭物的靶向部分都有用。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当药物组成以及它们的使用方法。
• Linkers useful for the synthesis of conjugates of methyltrithio
  申请人：American Cyanamid Company

  公开号：US05767285A1

  公开（公告）日：1998-06-16

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由强效抗肿瘤抗生素calicheamicin家族的二硫键类似物及其衍生物以及类似的esperamicins的类似物制备的载体-药物共轭物，载体可以是抗体、生长因子或类固醇，其针对不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及它们的抗原识别片段和它们的化学或基因操作的对应物对于共轭物的靶向部分是有用的。本发明包括用于这些共轭物的合成所需的化合物，载体-药物共轭物的适当药物组成以及它们的使用方法。
• Process for preparing conjugates of methyltrithio antitumor agents
  申请人：American Cyanamid Company

  公开号：US05877296A1

  公开（公告）日：1999-03-02

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了从卡利切阿霉素家族的二硫化物类似物及其衍生物以及类似的抗肿瘤抗生素如埃斯佩拉霉素中制备的载体-药物结合物，载体可以是抗体、生长因子或类固醇，其靶向不需要的细胞群体，例如肿瘤细胞。整个蛋白质载体以及其抗原识别片段以及其化学或基因操纵的对应物对于结合物的靶向部分是有用的。本发明包括合成这些结合物所需的化合物，载体-药物结合物的适当药物组成以及它们的使用方法。
• Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0689845A2

  公开（公告）日：1996-01-03

  This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

  本发明描述了由强效抗肿瘤抗生素卡利昔明家族的二硫类似物及其衍生物，以及相关抗肿瘤抗生素（如埃斯帕米星）的类似物制备的载体-药物共轭物。载体可以是一种抗体、生长因子或类固醇，它们可以靶向不需要的细胞群，如肿瘤细胞。整个蛋白质载体以及它们的抗原识别片段和经过化学或基因处理的对应物都可用于共轭物的靶向部分。本发明包括合成这些共轭物所需的化合物、载体-药物共轭物的适当药物组合物及其使用方法。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。