DCHO | 1318600-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: DCHO
• 英文别名: N-(2-hydroxyethyl)-2,5-di(4-formylphenyl)aniline
• CAS: 1318600-65-5
• 化学式: C₂₂H₁₉NO₃
• 分子量: 345.398
• InChiKey: DSIVAEMJRMDFEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  26.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  66.4
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  L-高半胱氨酸 、 DCHO 以 氘代二甲亚砜 为溶剂， 生成
  参考文献：
  名称：

  Tunable fluorescent sensing of cysteine and homocysteine by intramolecular charge transfer

  摘要：

  An amphiphilic oligo p-phenylene derivative (DCHO) bearing electron-donating group (-NH(CH2)2OH) and electron-withdrawing group (-CHO) has been synthesised and characterised. The sensing characteristics of this probe (DCHO) for cysteine (Cys) and homocysteine (Hcy) are studied in a mixture solution of DMSO-HEPES by UV-vis and fluorescence spectra. 1H NMR, MALDI-TOF and UV-vis titration experiments proved that thiazolidine and thiazinane derivatives were formed. The highly Cys/Hcy-selective fluorescence hypsochromic shift (110nm) can be observed due to the switching of intramolecular charge transfer, leading to potential fabrication of ratiometric fluorescent detection of Cys/Hcy.

  DOI：

  10.1080/10610271003759139
• 作为产物：
  描述：

  N-(2-hydroxyethyl)-2,5-dibromoaniline 、 4-甲酰基苯硼酸频哪醇酯 在 四(三苯基膦)钯 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 以61%的产率得到DCHO
  参考文献：
  名称：

  Tunable fluorescent sensing of cysteine and homocysteine by intramolecular charge transfer

  摘要：

  An amphiphilic oligo p-phenylene derivative (DCHO) bearing electron-donating group (-NH(CH2)2OH) and electron-withdrawing group (-CHO) has been synthesised and characterised. The sensing characteristics of this probe (DCHO) for cysteine (Cys) and homocysteine (Hcy) are studied in a mixture solution of DMSO-HEPES by UV-vis and fluorescence spectra. 1H NMR, MALDI-TOF and UV-vis titration experiments proved that thiazolidine and thiazinane derivatives were formed. The highly Cys/Hcy-selective fluorescence hypsochromic shift (110nm) can be observed due to the switching of intramolecular charge transfer, leading to potential fabrication of ratiometric fluorescent detection of Cys/Hcy.

  DOI：

  10.1080/10610271003759139