ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate | 75133-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate
• 英文别名: 2,3-dicyano-3-(4-methoxy-phenyl)-propionic acid ethyl ester；2,3-Dicyan-3-(4-methoxy-phenyl)-propionsaeure-aethylester；2-(4-Methoxy-phenyl)-aethan-tricarbonsaeure-(1.1.2)-1-aethylester-1.2-dinitril
• CAS: 75133-95-8
• 化学式: C₁₄H₁₄N₂O₃
• 分子量: 258.277
• InChiKey: WJRYUFXDOZMHSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.01
• 重原子数：
  19.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  83.11
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  ethyl 2,3-dicyano-3-(4-methoxyphenyl)propanoate 在 硫酸 作用下， 生成 2-(4-甲氧基苯基)-琥珀酸
  参考文献：
  名称：

  Optically Active Mono-substituted Succinic Acids and Derivatives

  摘要：

  DOI：

  10.1021/ja01866a053
• 作为产物：
  描述：

  ethyl (2E)-2-cyano-3-(4-methoxyphenyl)acrylate 、 氰化钠 以75%的产率得到
  参考文献：
  名称：

  CHATTERJEE A.; GHOSH S.; BASU N., INDIAN J. CHEM., 1980, B17, NO 6, 541-542

  摘要：

  DOI：

文献信息

• Eco-friendly conjugate hydrocyanation of α-cyanoacrylates using potassium hexacyanoferrate(II) as cyanating reagent
  作者：Yu-Peng Zhang、Xiao-Chun Hu、Zheng Li

  DOI：10.1515/chempap-2015-0055

  日期：2015.1.1

  The conjugate hydrocyanation of α-cyanoacrylates through chemoselective 1,4-addition to synthesise α,β-dicyanopropanoates by one-pot two-step procedure using potassium hexacyanoferrate(II) as an eco-friendly cyanide source, benzoyl chloride as a promoter and potassium carbonate as a catalyst is described. The advantages of this protocol are use of a non-toxic, non-volatile and inexpensive cyanating reagent

  使用六氰合铁酸钾（II）作为环境友好的氰化物源，苯甲酰氯作为促进剂和钾，通过一锅两步法通过化学选择的1,4-加成反应进行化学选择性的1,4-加成，使α-氰基丙烯酸酯共轭氢氰化描述了碳酸盐作为催化剂。该方案的优点是使用无毒，不挥发和廉价的氰化试剂，高产品收率和简单的操作程序。
• Chatterjee; Barpujari, Journal of the Indian Chemical Society, 1940, vol. 17, p. 292,294
  作者：Chatterjee、Barpujari

  DOI：——

  日期：——
• Siddiqui; Salah-ud-Din, Journal of the Indian Chemical Society, 1941, vol. 18, p. 635
  作者：Siddiqui、Salah-ud-Din

  DOI：——

  日期：——
• Novak; Protiva, Collection of Czechoslovak Chemical Communications, 1958, vol. 23, p. 663,666, 671
  作者：Novak、Protiva

  DOI：——

  日期：——
• Age and body make a difference in optimistic health beliefs and nutrition behaviors
  作者：Britta Renner、Nina Knoll、Ralf Schwarzer

  DOI：10.1207/s15327558ijbm0702_4

  日期：2000.6

  Nutrition behaviors are governed by health beliefs such as risk perceptions, outcome expectancies, and optimistic self-beliefs. This study deals with the role that objective criteria such as age and body weight might play in forming subjective beliefs. The question is whether they can deter people from forming an overly optimistic judgment of their health risk. Six kinds of verbal judgments were assessed, namely self-reported health, vulnerability toward cardiovascular diseases, nutrition outcome expectancies, nutrition self-efficacy, intentions to change one's diet, and reported nutrition behaviors. Tn a sample of 1,583 men and women between 14 and 87 years of age, these judgments were statistically related to age and body weight. It was found that people do take their objective risk status into account, but only to a certain degree. The self-serving bias continues to exist throughout all age groups and weight levels. Moreover, it was found that individuals report better intentions to adhere to healthy foods and better nutrition behaviors as they grow older and gain weight.