6-(decyloxy)hexanol | 138060-31-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(decyloxy)hexanol
• 英文别名: 7-Oxaheptadecanol-1；6-decyloxy-hexan-1-ol；6-Decoxyhexan-1-ol
• CAS: 138060-31-8
• 化学式: C₁₆H₃₄O₂
• 分子量: 258.445
• InChiKey: FDDZKWXXNHZUEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  18
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(decyloxy)hexanol 以 四氢呋喃 、 乙腈 为溶剂， 反应 36.0h， 生成
  参考文献：
  名称：

  4-Substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists

  摘要：

  A series of 4-substituted 2-alkoxytetrahydrofuran derivatives featuring an acetal group were prepared and evaluated for PAF antagonist activity in the PAF-induced in vitro platelet-aggregation and in vivo hypotension tests. Compound 2-[[N-acetyl-N-[[[2-(octadecyloxy)tetrahydrofuran-4-yl]methoxy]carbonyl]amino]methyl]1-ethylpyridinium chloride (4e, UR-11353) was selected for further development on the basis of its high activity and long-lasting action. The compound maintained a significant activity even 24 h after administration of a single dose of 1 mg/kg iv in the PAF-induced mortality test in mice and 10 h after administration of the same dose in the PAF-induced hypotension test in rats. Comparison with previously reported carba analogues suggests that the presence of the acetal group is the structural characteristic that confers its long-lasting activity.

  DOI：

  10.1021/jm00082a007