ethyl 6-(5-methyl-1,3-dioxo-isoindol-2-yl)hexanoate | 1001338-14-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 6-(5-methyl-1,3-dioxo-isoindol-2-yl)hexanoate
• 英文别名: Ethyl 6-(5-methyl-1,3-dioxoisoindol-2-yl)hexanoate
• CAS: 1001338-14-2
• 化学式: C₁₇H₂₁NO₄
• 分子量: 303.358
• InChiKey: QECPYOYIGPVDGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• NOVEL DERIVATIVES OF PHTHALIMIDE AS HISTONE DEACETYLASE INHIBITORS
  申请人：Gomez Vidal Jose Antonio

  公开号：US20110003878A1

  公开（公告）日：2011-01-06

  The invention relates to novel compounds of general formula (I), or one of the salts thereof, particularly one of the pharmaceutically acceptable salts thereof, or one of the corresponding solvates thereof. These compounds are inhibitors of the histone deacetylase enzymes and are suitable as pharmacologically active agents in a medicament for the treatment and/or prophylaxis of disorders or diseases associated with histone deacetylases. The invention also relates to a process for obtaining the mentioned compounds and the pharmaceutical compositions containing them.

  本发明涉及一般式（I）的新化合物，或其盐之一，特别是其药学上可接受的盐之一，或其相应的溶剂化物之一。这些化合物是组蛋白去乙酰化酶的抑制剂，并且适用于作为药物中的药理活性剂，用于治疗和/或预防与组蛋白去乙酰化酶相关的疾患或疾病。本发明还涉及获得上述化合物的方法和含有它们的制药组合物。