LY-2090314 ethanol solvate | 1097945-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: LY-2090314 ethanol solvate
• 英文别名: ethanol;3-[6-fluoro-10-(piperidine-1-carbonyl)-1,10-diazatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-4-imidazo[1,2-a]pyridin-3-ylpyrrole-2,5-dione
• CAS: 1097945-23-7
• 化学式: C30H31FN6O4
• 分子量: 558.6
• InChiKey: PQDRKXRENQDFMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.42
• 重原子数：
  41
• 可旋转键数：
  2
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• HEMATOPOIETIC NEOPLASM CHEMOTHERAPY
  申请人：Chedid Marcio

  公开号：US20100261712A1

  公开（公告）日：2010-10-14

  A method and medicament for treating mixed lineage leukemia; translocated mixed lineage leukemia; translocated mixed lineage leukemia based acute myelogenous leukemia; translocated mixed lineage leukemia based acute lymphoid leukemia; a non-MLL based chronic myeloproliferative disorder, or non-MLL based acute lymphoid leukemia is provided.

  本发明提供了一种治疗混合谱系白血病的方法和药物；移位混合谱系白血病；基于移位混合谱系白血病的急性髓系白血病；基于移位混合谱系白血病的急性淋巴细胞白血病；非MLL基础的慢性增生性骨髓疾病或非MLL基础的急性淋巴细胞白血病的药物。
• POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE
  申请人：Aburub Aktham

  公开号：US20100166884A1

  公开（公告）日：2010-07-01

  A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4]benzodiazepine, useful for the method and a process for preparing said compositions.

  本发明涉及一种治疗患有胃癌、卵巢癌、非小细胞肺癌或结直肠癌的患者的方法，以及包含7-(2,5-二氢咪唑[1,2-a]吡啶-3-基)-2,5-二氧代-IH-吡咯-3-基)-9-氟-1,2,3,4-四氢-2-(1-哌啶基-羰基)-吡咯[3,2,1-jk][1,4]苯二氮平的制药组合物，用于该方法和制备该组合物的过程。
• POTENTIATION OF CANCER CHEMOTHERAPY BY 7-(2, 5- DIHYDRO- 4-IMIDAZO [1, 2-A] PYRIDINE-3-YL-2,5-DIOXO-IH-PYRROL-3-YL)-9-FLUORO-1,2,3,4 TETRAHYDRO -2-(1-PIPERIDINYL-CARBONYL)-PYRROLO [3,2,1-JK] [1,4] BENZODIAZEPINE
  申请人：ELI LILLY AND COMPANY

  公开号：US20130039996A1

  公开（公告）日：2013-02-14

  An improved method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions useful for the method and a process for preparing said compositions.

  本发明描述了一种改进的方法，用于治疗患有胃癌、卵巢癌、非小细胞肺癌或结直肠癌的患者，以及用于该方法的制药组合物和制备该组合物的过程。
• POTENTIATION OF CANCER CHEMOTHERAPY
  申请人：Eli Lilly & Company

  公开号：EP2173348B1

  公开（公告）日：2015-12-09
• BENZODIAZEPINE DERIVATIVE FOR THE TREATMENT OF HEMATOPOIETIC NEOPLASM AND LEUKEMIA
  申请人：Eli Lilly and Company

  公开号：EP2419106A1

  公开（公告）日：2012-02-22