3-[2-(4-bromo-3-chloroanilino)-2-oxoethyl]-1H-indole-2-carboxylic acid | 1069110-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-[2-(4-bromo-3-chloroanilino)-2-oxoethyl]-1H-indole-2-carboxylic acid
• CAS: 1069110-70-8
• 化学式: C₁₇H₁₂BrClN₂O₃
• 分子量: 407.651
• InChiKey: BMSOPEUMDCACDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  82.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Novel Compounds for Enhancing MHC Class II Therapies
  申请人：Wucherpfennig Kai W.

  公开号：US20100183658A1

  公开（公告）日：2010-07-22

  The invention provides classes of novel compounds that accelerate peptide loading to DR in the absence of DM and related pharmaceutical compositions. The invention also provides conjugates of these compounds with peptides, antigens or other MHC-based therapeutics, including peptides that self-catalyze their loading onto MHC Class II molecules. Methods are provided for modulating an immune response in a subject. Also disclosed are methods of using the novel compounds, e.g., in combination with MHC-based therapeutics, for the treatment of autoimmune diseases and for the manufacture of medicaments. Methods of improving loading of viral peptides and tumor peptides for enhancing the CD4 T cell response following vaccination against viruses or tumors, and related vaccines, are also provided.

  本发明提供了一类新化合物，可以在没有DM的情况下加速肽负载到DR，并提供相关的制药组合物。本发明还提供这些化合物与肽、抗原或其他基于MHC的治疗药物的共轭物，包括自催化其负载到MHC II类分子的肽。本发明提供了用于调节受体免疫应答的方法。还公开了使用新化合物的方法，例如与基于MHC的治疗药物结合，用于治疗自身免疫性疾病和制药的制造方法。还提供了提高病毒肽和肿瘤肽负载以增强CD4 T细胞应答的方法和相关疫苗。