5-Fluoro-1H-pyrazolo[4,3-B]pyridine | 1260670-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 5-Fluoro-1H-pyrazolo[4,3-B]pyridine
• CAS: 1260670-02-7
• 化学式: C₆H₄FN₃
• 分子量: 137.11
• InChiKey: LTYNYHHABUSSHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted 5-fluoro-1H-pyrazolopyridines and their use
  申请人：Follmann Markus

  公开号：US20120022084A1

  公开（公告）日：2012-01-26

  The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代的5-氟-1H-吡唑吡啶衍生物，其制备方法，单独或与其他药物联合治疗和/或预防疾病的用途，以及用于制备治疗和/或预防疾病的药物的用途，特别是用于治疗和/或预防心血管疾病。
• Process for preparing substituted 5-fluoro-1H-pyrazolopyridines
  申请人：BAYER INTELLECTUAL PROPERTY GMBH

  公开号：US20130143900A1

  公开（公告）日：2013-06-06

  The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及一种新颖高效的制备新型取代5-氟-1H-吡唑吡啶的方法，其化学式为（VI），该方法适用于作为药物制剂的中间体，用于制备治疗和/或预防心血管疾病的药物。更具体地说，化学式（VI）的5-氟-1H-吡唑吡啶适用于制备化合物的化学式（I），该化合物用于药物制剂的制备，用于制备治疗和/或预防心血管疾病的药物。
• [EN] PROCESS FOR MANUFACTURING 4-(2,2,3,3-TETRAFLUOROPROPYL)MORPHOLINE<br/>[FR] PROCÉDÉ DE FABRICATION DE 4-(2,2,3,3-TÉTRAFLUOROPROPYL)MORPHOLINE
  申请人：ADVERIO PHARMA GMBH

  公开号：WO2020152010A1

  公开（公告）日：2020-07-30

  The present application relates to a novel, cost-saving and efficient process for preparing 4-(2,2,3,3-tetrafluoropropyl)morpholine which serves as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及一种新型、节省成本、高效的制备4-(2,2,3,3-四氟丙基)吗啡啶的方法，该方法用作制药中间体以及用于制备用于治疗和/或预防心血管疾病的药物。
• SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND THEIR USE
  申请人：BAYER INTELLECTUAL PROPERTY GmbH

  公开号：US20150080414A1

  公开（公告）日：2015-03-19

  The present application relates to novel substituted 5-fluoro-1H-pyrazolopyridines, to processes for their preparation, to their use alone or in combinations for the treatment and/or prophylaxis of diseases, and to their use for producing medicaments for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular disorders.

  本申请涉及新型取代的5-氟-1H-吡唑吡啶，其制备方法，其单独或与其他药物联合用于治疗和/或预防疾病，以及其用于制备治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
• [DE] SUBSTITUIERTE 5-FLUOR-1H-PYRAZOLOPYRIDINE UND IHRE VERWENDUNG<br/>[EN] SUBSTITUTED 5-FLUORO-1H-PYRAZOLOPYRIDINES AND USE THEREOF<br/>[FR] 5-FLUORO-1H-PYRAZOLOPYRIDINES SUBSTITUÉES ET LEUR UTILISATION
  申请人：BAYER PHARMA AG

  公开号：WO2011147809A1

  公开（公告）日：2011-12-01

  Die vorliegende Anmeldung betrifft neue substutuierte 5-Fluor-lH-Pyrazolopyridine, Verfahren zu ihrer Herstellung, ihre Verwendung allein oder in Kombinationen zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, insbesondere zur Behandlung und/oder Prophylaxe von Herz-Kreislauf-Erkrankungen.

  这份申请涉及新的取代5-氟-1H-吡唑吡啶，其制备方法，其单独或与其他物质联合使用以治疗和/或预防疾病以及其用于制造治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。