1-(2-bromobenzyl)-5-bromo-3-(3-(pyrrolidin-1-yl)-1-hydroxypropyl)-1H-indole | 639809-14-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(2-bromobenzyl)-5-bromo-3-(3-(pyrrolidin-1-yl)-1-hydroxypropyl)-1H-indole
• 英文别名: 1-(2-bromobenzyl)-5-bromo-3-(3-(pyrrolidin-1-yl)-1-hydroxypropyl)-1H-indol；1-[5-Bromo-1-[(2-bromophenyl)methyl]indol-3-yl]-3-pyrrolidin-1-ylpropan-1-ol
• CAS: 639809-14-6
• 化学式: C₂₂H₂₄Br₂N₂O
• 分子量: 492.253
• InChiKey: BUZNGRCDWUMOJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  28.4
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] ARYLALKYL INDOLES HAVING SERTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] ARYLALKYL INDOLES A AFFINITE DE RECEPTEUR DE LA SEROTONINE UTILISES COMME AGENTS THERAPEUTIQUES, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES CONTENANT LESDITS INDOLES
  申请人：SUVEN PHARMACEUTICALS LTD

  公开号：WO2004000845A1

  公开（公告）日：2003-12-31

  The present invention relates to novel tetracyclic arylalkyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylalkyl of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy.

  本发明涉及新型四环芳基烷基吲哚化合物，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药用可接受的盐，药用可接受的溶剂化合物，本文描述的新中间体以及含有它们的药用可接受的组合物。本发明特别涉及一般式（I）的新型四环芳基烷基化合物，其衍生物，类似物，互变异构体，立体异构体，多晶形态，药用可接受的盐，药用可接受的溶剂化合物，本文描述的新中间体以及含有它们的药用可接受的组合物。本发明还涉及制备一般式（I）化合物的方法/方法，含有这种化合物的有效量/量的组合物以及这种化合物/组合物在治疗中的使用。
• ARYLALKYL INDOLES HAVING SEROTONIN RECEPTOR AFFINITY USEFUL AS THERAPEUTIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Suven Pharmaceuticals Ltd.

  公开号：EP1537113A1

  公开（公告）日：2005-06-08