3-(6-amino-1,3,4,9-tetrahydro-b-carbolin-2-yl)-propane-1-sulfonic acid | 393175-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(6-amino-1,3,4,9-tetrahydro-b-carbolin-2-yl)-propane-1-sulfonic acid
• 英文别名: 3-(6-Amino-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)propane-1-sulfonic acid
• CAS: 393175-70-7
• 化学式: C₁₄H₁₉N₃O₃S
• 分子量: 309.389
• InChiKey: YBZBAYHKRHNIKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  108
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Methods and compositions for treating amyloid-related diseases
  申请人：Kong Xianqi

  公开号：US20070010573A1

  公开（公告）日：2007-01-11

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  描述了用于治疗或预防与淀粉样蛋白相关的疾病的方法、化合物、制药组合物和试剂盒。
• METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES
  申请人：Kong Xianqi

  公开号：US20100113591A1

  公开（公告）日：2010-05-06

  Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

  本发明涉及用于治疗或预防淀粉样蛋白相关疾病的方法、化合物、制药组合物和试剂盒。
• Amyloid targeting imaging agents and uses thereof
  申请人：——

  公开号：US20020115717A1

  公开（公告）日：2002-08-22

  Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeting imaging agents that are useful for imaging sites of amyloid disease. Imaging agents of the invention are capable of binding specifically to amyloid plaques, as an aid in diagnosis and/or early treatment of amyloidosis disorders.

  淀粉样蛋白靶向成像剂，如放射性标记的淀粉样蛋白靶向分子和淀粉样蛋白靶向分子-螯合剂共轭物，用于例如体内淀粉样蛋白斑块的成像，和/或用于淀粉样变性疾病的治疗。本发明提供的淀粉样蛋白靶向成像剂可用于淀粉样蛋白疾病部位的成像。本发明的成像剂能够与淀粉样蛋白斑块特异性结合，有助于淀粉样变性疾病的诊断和/或早期治疗。
• AMYLOID TARGETING IMAGING AGENTS AND USES THEREOF
  申请人：Neurochem, Inc.

  公开号：EP1303311A2

  公开（公告）日：2003-04-23
• Pharmaceutical drug candidates and methods for preparation thereof
  申请人：Kong Xianqi

  公开号：US20050143462A1

  公开（公告）日：2005-06-30

  The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.