2,5-dioxopyrrolidin-1-yl methyl glutarate | 1511700-07-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,5-dioxopyrrolidin-1-yl methyl glutarate
• 英文别名: Pentanedioic acid 2,5-dioxo-pyrrolidin-1-yl ester methyl ester；5-O-(2,5-dioxopyrrolidin-1-yl) 1-O-methyl pentanedioate
• CAS: 1511700-07-4
• 化学式: C₁₀H₁₃NO₆
• 分子量: 243.216
• InChiKey: VGVQMVBXFLYTSS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  90
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2,5-dioxopyrrolidin-1-yl methyl glutarate 在 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 9.0h， 生成
  参考文献：
  名称：

  Polystyrene-supported neutral lithium receptor for the recovery of high-purity LiPF₆ from simulated degraded electrolyte

  摘要：

  将中性锂选择性受体双二环己基乙酰胺（BDCA）固定在聚苯乙烯树脂上，可通过溶剂极性切换捕捉和释放 LiPF6。

  DOI：

  10.1039/d2ta03220a
• 作为产物：
  描述：

  N-羟基丁二酰亚胺 、 戊二酸单甲酯 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 以90%的产率得到2,5-dioxopyrrolidin-1-yl methyl glutarate
  参考文献：
  名称：

  Polystyrene-supported neutral lithium receptor for the recovery of high-purity LiPF₆ from simulated degraded electrolyte

  摘要：

  将中性锂选择性受体双二环己基乙酰胺（BDCA）固定在聚苯乙烯树脂上，可通过溶剂极性切换捕捉和释放 LiPF6。

  DOI：

  10.1039/d2ta03220a

文献信息

• Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions
  作者：Jun Yang、Yong Liang、Jolita Šečkutė、K. N. Houk、Neal K. Devaraj

  DOI：10.1002/chem.201304225

  日期：2014.3.17

  Substituted cyclopropenes have recently attracted attention as stable “mini‐tags” that are highly reactive dienophiles with the bioorthogonal tetrazine functional group. Despite this interest, the synthesis of stable cyclopropenes is not trivial and their reactivity patterns are poorly understood. Here, the synthesis and comparison of the reactivity of a series of 1‐methyl‐3‐substituted cyclopropenes with

  取代的环丙烯最近作为稳定的“微型标签”引起了人们的注意，它们是具有生物正交四嗪官能团的高反应性亲二烯体。尽管有这种兴趣，但稳定环丙烯的合成并非微不足道，并且对其反应模式知之甚少。在这里，描述了一系列具有不同功能手柄的 1-甲基-3-取代环丙烯的反应性的合成和比较。测量了各种取代的环丙烯与 1,2,4,5-四嗪进行 Diels-Alder 环加成反应的速率。根据取代基的不同，环加成的速率变化超过两个数量级。取代基对水性稳定性也有显着影响。这些研究的一个结果是发现了一种新的 3-酰胺甲基取代的甲基环丙烯标签，其反应速度是先前公开的最快的 1-甲基-3-取代的环丙烯的两倍，同时保持优异的水性稳定性。此外，这种新的环丙烯更适合生物偶联应用，这通过使用 DNA 模板四嗪连接得到证明。还研究了四嗪结构对环丙烯反应速率的影响。令人惊讶的是，3-酰胺甲基取代的甲基环丙烯的反应速度比 还研究了四嗪结构对环丙
• BIOCOMPATIBLE CROSSLINKED HYDROGELS, DRUG-LOADED HYDROGELS AND METHODS OF USING THE SAME
  申请人：He Yuehua

  公开号：US20160228601A1

  公开（公告）日：2016-08-11

  Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.

  本发明公开了一种由四甲基甲烷与一种或多种聚乙二醇混合形成的水凝胶组合物，其中每个聚乙二醇取代基独立地进一步取代有一种或多种亲电基团，以及一种或多种聚乙二醇取代的四甲基甲烷，其中每个聚乙二醇取代基独立地进一步取代有一种或多种亲核基团。本发明还公开了制备上述水凝胶的方法。该水凝胶组合物可以进一步包含药物，例如止痛剂或局部麻醉剂。本发明还公开了使用上述水凝胶密封创伤、预防术后粘连和减轻术后疼痛的方法。
• Hair treatment composition, hair treatment agent and method for treating hair by using the same
  申请人：Sunbio, Inc.

  公开号：EP1938795A2

  公开（公告）日：2008-07-02

  The present invention relates to a hair treatment composition comprising a multi-arm polyethylene glycol derivative (A) containing two or more functional groups that may be covalently bound to amine, a hair treatment composition comprising a polyethylene glycol derivative (B), containing one or more functional groups that may react with the functional groups of said composition, and/or a biocompatible polymer (C), a hair treatment agent comprising these compositions and a method for using the same. The hair treatment agent of the present invention is capable of increasing the hair thickness and volume, restoring the damaged hair and lasting the hair shape and curls for a long time, by firstly covalently binding some functional groups of said polyethylene glycol derivative (A) to amino acids present on hair surfaces and then covalently binding some functional groups not covalently bound to hair, to a polyethylene glycol derivative (B) and/or a biocompatible polymer (C).

  本发明涉及一种头发治疗组合物，该组合物包含一种多臂聚乙二醇衍生物（A），其中含有两个或多个可与胺共价结合的官能团；一种头发治疗组合物，该组合物包含一种聚乙二醇衍生物（B），其中含有一个或多个可与所述组合物的官能团反应的官能团，和/或一种生物相容性聚合物（C）；一种头发治疗剂，该头发治疗剂包含这些组合物，以及使用这些组合物的方法。本发明的头发治疗剂首先将所述聚乙二醇衍生物（A）的一些官能团与存在于头发表面的氨基酸共价结合，然后将一些未与头发共价结合的官能团与聚乙二醇衍生物（B）和/或生物相容性聚合物（C）共价结合，从而能够增加头发的厚度和发量，恢复受损的头发，并长期保持头发的形状和卷曲度。
• Influencing Antibody-Mediated Attenuation of Methamphetamine CNS Distribution through Vaccine Linker Design
  作者：Major Gooyit、Pedro O. Miranda、Cody J. Wenthur、Alex Ducime、Kim D. Janda

  DOI：10.1021/acschemneuro.6b00389

  日期：2017.3.15

  Active vaccination examining a single hapten engendered with a series of peptidic linkers has resulted in the production of antimethamphetamine antibodies. Given the limited chemical complexity of methamphetamine, the structure of the linker species embedded within the hapten could have a substantial effect on the ultimate efficacy of the resulting vaccines. Herein, we investigate linker effects by generating a series of methamphetamine haptens that harbor a linker with varying amino acid identity, peptide length, and associated carrier protein. Independent changes in each of these parameters were found to result in alterations in both the quantity and quality of the antibodies induced by vaccination. Although it was found that the consequence of the linker design was also dependent on the identity of the carrier protein, we demonstrate overall that the inclusion of a short, structurally simple, amino acid linker benefits the efficacy of a methamphetamine vaccine in limiting brain penetration of the free drug.
• LONG DURATION DUAL HORMONE CONJUGATES
  申请人：ASTRAZENECA PHARMACEUTICALS, LP

  公开号：US20140221282A1

  公开（公告）日：2014-08-07

  There are provided compounds having two peptide hormones bound to a central water-soluble polymeric spacer and methods of use thereof.