3-羟基-2-甲氧基四氢呋喃 | 33691-67-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 中文名称: 3-羟基-2-甲氧基四氢呋喃
• 英文名称: 1-methoxy-2-hydroxytetrahydrofuran
• 英文别名: 2-methoxytetrahydrofuran-3-ol；methyl 2-hydroxyfuranoside；2-methoxy-tetrahydro-furan-3-ol；2-Methoxy-3-hydroxytetrahydrofuran；2-methoxyoxolan-3-ol
• CAS: 33691-67-7
• 化学式: C₅H₁₀O₃
• 分子量: 118.133
• InChiKey: DDIDZOMSYGWECH-UHFFFAOYSA-N

物化性质

• 沸点：
  209℃
• 密度：
  1.13
• 闪点：
  80℃

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-羟基-2-甲氧基四氢呋喃 在 Dowex AG-50W-X₈ (H(+) form) 水 作用下， 反应 36.0h， 生成 3-Deoxy-DL-glycero-tetrose
  参考文献：
  名称：

  Substrate specificity and carbohydrate synthesis using transketolase

  摘要：

  This paper describes the use of the enzyme transketolase as a catalyst in organic synthesis. The properties of transketolase from both yeast and spinach were investigated. The yeast enzyme was found to be more convenient for routine use. Examination of the substrate specificity of yeast transketolase demonstrated that the enzyme accepts a wide variety of 2-hydroxy aldehydes as substrates. A practical protocol for transketolase-catalyzed condensation of hydroxypyruvic acid with these aldehydes has been developed and used for the synthesis of four carbohydrates: L-idose, L-gulose, 2-deoxy-L-xylohexose, and L-xylose.

  DOI：

  10.1021/jo00048a023
• 作为产物：
  描述：

  2,3-二氢呋喃 、 甲醇 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 反应 15.25h， 生成 3-羟基-2-甲氧基四氢呋喃
  参考文献：
  名称：

  [EN] HETEROCYCLIC AMIDES AS ROCK INHIBITORS
  [FR] AMIDES HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE ROCK

  摘要：

  公开号：

  WO2011107608A8

文献信息

• Template-directed intramolecular C-glycosidation. cation-mediated synthesis of ketooxetanes from thioglycosides
  作者：Donald Craig、V.Ranjit N. Munasinghe、Jason P. Tierney、Andrew J.P. White、David J. Williams、Christopher Williamson

  DOI：10.1016/s0040-4020(99)00959-x

  日期：1999.12

  Bicyclic ketooxetanes may be assembled using cation-mediated cyclisation reactions of thioglycosides possessing silyl enol ether-containing side-chains.

  可以使用具有含甲硅烷基烯醇醚的侧链的硫代糖苷的阳离子介导的环化反应来组装双环酮肟烷。
• HETEROCYCLIC AMIDES AS ROCK INHIBITORS
  申请人：Leysen Dirk

  公开号：US20120322801A1

  公开（公告）日：2012-12-20

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，包括这些抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这些抑制剂在治疗和预防疾病方面的用途。特别是，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这些抑制剂在治疗和预防疾病方面的用途。此外，本发明还涉及治疗和使用所述化合物制造药物的方法，应用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• NOVEL ROCK INHIBITORS
  申请人：Amakem NV

  公开号：US20130252975A1

  公开（公告）日：2013-09-26

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地，是ROCK抑制剂，包括这种抑制剂的组合物，特别是制药组合物，并且涉及这种抑制剂在治疗和预防疾病方面的用途。特别地，本发明涉及新的ROCK抑制剂，包括这种抑制剂的组合物，特别是制药组合物，并且涉及这种抑制剂在治疗和预防疾病方面的用途。此外，本发明还涉及使用该化合物的治疗方法和制造药物的用途，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• Rock inhibitors
  申请人：Amakem NV

  公开号：US08912209B2

  公开（公告）日：2014-12-16

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地涉及ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及这些抑制剂在治疗和预防疾病中的用途。特别地，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及这些抑制剂在治疗和预防疾病中的用途。此外，本发明涉及治疗方法和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。
• Heterocyclic amides as rock inhibitors
  申请人：Leysen Dirk

  公开号：US08815873B2

  公开（公告）日：2014-08-26

  The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.

  本发明涉及新的激酶抑制剂，更具体地说是ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病方面使用这些抑制剂的用途。特别地，本发明涉及新的ROCK抑制剂，包括这些抑制剂的组合物，特别是制药组合物，以及在治疗和预防疾病方面使用这些抑制剂的用途。此外，本发明还涉及使用该化合物的治疗方法和用于制造药物的应用，适用于多种治疗适应症，包括性功能障碍、炎症性疾病、眼科疾病和呼吸系统疾病。