4-(1-Methyl-1H-pyrrol-3-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxamide | 918133-04-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 4-(1-Methyl-1H-pyrrol-3-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxamide
• 英文别名: 4-(1-methylpyrrol-3-yl)-1H-pyrazolo[3,4-b]pyridine-6-carboxamide
• CAS: 918133-04-7
• 化学式: C₁₂H₁₁N₅O
• 分子量: 241.252
• InChiKey: KJOXFMTXKUTHAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Pyrazolopyridine derivatives as inhibitors of beta-Adrenergic Receptor Kinase 1
  申请人：STEINHAGEN Henning

  公开号：US20080227777A1

  公开（公告）日：2008-09-18

  The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.

  本发明涉及式(I)的6-酰胺取代吡唑吡啶衍生物，其可用作β-肾上腺素能受体激酶1（βARK-1）的抑制剂，包含这种化合物的组合物以及它们用于治疗和预防慢性心力衰竭、高血压、心肌缺血和丙型肝炎病毒（HCV）感染以及预防鸦片成瘾的用途。
• US7910602B2
  申请人：——

  公开号：US7910602B2

  公开（公告）日：2011-03-22
• [EN] PYRAZOLOPYRIDINE DERIVATIVES AS INHIBITORS OF BETA-ADRENERGIC RECEPTOR KINASE 1<br/>[FR] DERIVES DE PYRAZOLOPYRIDINE UTILISES EN TANT QU'INHIBITEURS DE LA KINASE 1 DU RECEPTEUR $G(B)-ADRENERGIQUE
  申请人：SANOFI AVENTIS DEUTSCHLAND

  公开号：WO2007000241A1

  公开（公告）日：2007-01-04

  [EN] The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (ßARK-1 ), compositions containing such-compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.
  [FR] L'invention concerne des dérivés de pyrazolopyridine 6-amido substitués de formule (I) utiles en tant qu'inhibiteurs de la kinase 1 du récepteur bêta-adrénergique (ßARK-1), des compositions contenant lesdits composés et leur utilisation pour le traitement et la prévention de l'insuffisance cardiaque chronique, de l'hypertension, de l'ischémie myocardique et d'infections par le virus de l'hépatite C (HCV), ainsi que pour la prévention de la toxicomanie opiacée.
• [EN] METHODS AND COMPOSITIONS FOR TREATING CANCER<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DU CANCER
  申请人：FLAGSHIP PIONEERING INNOVATIONS V INC

  公开号：WO2021046225A1

  公开（公告）日：2021-03-11

  The present invention provides methods for treating cancer using GRK2 inhibitors such as small molecule inhibitors of GRK2 among others. The invention also features compositions containing GRK2 inhibitors, methods of diagnosing patients with GRK2-associated cancer and methods of predicting the response of cancer in a subject to treatment with GRK2 inhibitors.