4-<4-Methoxy-phenyl>-furo <3.2-c> pyridin | 96953-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-<4-Methoxy-phenyl>-furo <3.2-c> pyridin
• 英文别名: 4-(4-methoxy-phenyl)-furo[3,2-c]pyridine；4-(4-Methoxyphenyl)furo[3,2-c]pyridine
• CAS: 96953-82-1
• 化学式: C₁₄H₁₁NO₂
• 分子量: 225.247
• InChiKey: DINMGFRWKDMVCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  iridium(III) chloride trihydrate 、 乙酰丙酮 、 4-<4-Methoxy-phenyl>-furo <3.2-c> pyridin 在 sodium carbonate 作用下， 以 乙二醇乙醚 、 水 为溶剂， 反应 60.0h， 以61%的产率得到
  参考文献：
  名称：

  Methoxyl modification in furo[3,2-c]pyridine-based iridium complexes towards highly efficient green- and orange-emitting electrophosphorescent devices

  摘要：

  通过对基于呋[3,2-c]吡啶的Ir配合物进行简单的甲氧基修饰，成功实现了高效的绿色和橙色发光PhOLEDs。

  DOI：

  10.1039/c7tc04269h
• 作为产物：
  描述：

  4-甲氧基苯硼酸 、 4-氯呋喃基吡啶 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 8.0h， 以75%的产率得到4-<4-Methoxy-phenyl>-furo <3.2-c> pyridin
  参考文献：
  名称：

  Methoxyl modification in furo[3,2-c]pyridine-based iridium complexes towards highly efficient green- and orange-emitting electrophosphorescent devices

  摘要：

  通过对基于呋[3,2-c]吡啶的Ir配合物进行简单的甲氧基修饰，成功实现了高效的绿色和橙色发光PhOLEDs。

  DOI：

  10.1039/c7tc04269h

文献信息

• Heteroaromatic Compounds and their Use as Dopamine D1 Ligands
  申请人：PFIZER INC.

  公开号：US20150291625A1

  公开（公告）日：2015-10-15

  The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses.

  本发明部分提供了公式I的化合物：及其药学上可接受的盐和N-氧化物；其制备的过程和中间体；以及其组合物和用途。本发明进一步提供具有减少D1R脱敏作用的D1激动剂，具有相对于多巴胺减少β-阻滞素招募活性的D1激动剂，当结合到D1R时与Ser188显著相互作用但与Ser202显著相互作用较少的D1激动剂，与D1R结合时与Asp103相互作用较弱且与Ser198相互作用较弱的D1激动剂及其用途。
• Organic metal compound, organic light-emitting devices employing the same
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US10340466B2

  公开（公告）日：2019-07-02

  Organic metal compounds, and organic light-emitting devices employing the same are provided. The organic metal compound has a chemical structure represented by Formula (I) or Formula (II): wherein, R1 is hydrogen, C1-12 alkyl, C1-12 alkoxy, amine, C2-6 alkenyl, C2-6 alkynyl, C5-10 cycloalkyl, C3-12 heteroaryl, or C6-12 aryl; R2, R3, R4, and R5 can be hydrogen, halogen, C1-12 alkyl, C1-12 alkoxy, C1-12 fluoroalkyl; R6 and R7 are independent and can be C1-6 alkyl, or phenyl; R8, R9, R10, R11, R12, R13, R14, and R15 can be hydrogen, halogen, C1-12 alkyl, C1-12 fluoroalkyl, or two adjacent groups of R2, R3, R4, R5, R8, R9, R10, R11, R12, R13, R14 and R15 are optionally combined with the carbon atoms which they are attached to, to form a cycloalkyl group, or aryl; m is 1 or 2; and, n is 0 or 1.

  本发明提供了有机金属化合物和采用有机金属化合物的有机发光器件。有机金属化合物的化学结构由式（I）或式（II）表示： 其中，R1是氢、C1-12烷基、C1-12烷氧基、胺、C2-6烯基、C2-6炔基、C5-10环烷基、C3-12杂芳基或C6-12芳基；R2、R3、R4和R5可以是氢、卤素、C1-12烷基、C1-12烷氧基、C1-12氟烷基；R6和R7是独立的，可以是C1-6烷基或苯基；R8、R9、R10、R11、R12、R13、R14 和 R15 可以是氢、卤素、C1-12 烷基、C1-12 氟烷基，或者 R2、R3、R4、R5、R8、R9、R10、R11、R12、R13、R14 和 R15 的两个相邻基团与它们所连接的碳原子任选结合形成环烷基或芳基；m 是 1 或 2；n 是 0 或 1。
• HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS
  申请人：Pfizer Inc.

  公开号：EP2917219B1

  公开（公告）日：2017-09-27
• ORGANIC METAL COMPOUND, ORGANIC LIGHT-EMITTING DEVICES EMPLOYING THE SAME
  申请人：INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

  公开号：US20170155065A1

  公开（公告）日：2017-06-01

  Organic metal compounds, and organic light-emitting devices employing the same are provided. The organic metal compound has a chemical structure represented by Formula (I) or Formula (II): wherein, R 1 is hydrogen, C 1-12 alkyl, C 1-12 alkoxy, amine, C 2-6 alkenyl, C 2-6 alkynyl, C 5-10 cycloalkyl, C 3-12 heteroaryl, or C 6-12 aryl; R 2 , R 3 , R 4 , and R 5 can be hydrogen, halogen, C 1-12 alkyl, C 1-12 alkoxy, C 1-12 fluoroalkyl; R 6 and R 7 are independent and can be C 1-6 alkyl, or phenyl; R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 , and R 15 can be hydrogen, halogen, C 1-12 alkyl, C 1-12 fluoroalkyl, or two adjacent groups of R 2 , R 3 , R 4 , R 5 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 and R 15 are optionally combined with the carbon atoms which they are attached to, to form a cycloalkyl group, or aryl; m is 1 or 2; and, n is 0 or 1.
• US9617275B2
  申请人：——

  公开号：US9617275B2

  公开（公告）日：2017-04-11