3-羟基-3-甲基丁酸叔丁酯 | 5292-12-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-羟基-3-甲基丁酸叔丁酯
• 英文名称: 3-Hydroxy-3-methyl-buttersaeure-tert-butylester
• 英文别名: Tert-butyl 3-hydroxy-3-methylbutanoate
• CAS: 5292-12-6
• 化学式: C₉H₁₈O₃
• 分子量: 174.24
• InChiKey: JCNCOCSBOVSNTK-UHFFFAOYSA-N

物化性质

• 沸点：
  82-82.5 °C(Press: 19 Torr)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2918199090

反应信息

• 作为反应物：
  描述：

  3-羟基-3-甲基丁酸叔丁酯 在 1,4-二氧六环 、 盐酸 作用下， 生成 β-羟基异戊酸
  参考文献：
  名称：

  Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism

  摘要：

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.

  DOI：

  10.1385/bter:74:1:55
• 作为产物：
  描述：

  醋酸叔丁酯 在 乙醚 、 异丙基氯化镁 作用下， 生成 3-羟基-3-甲基丁酸叔丁酯
  参考文献：
  名称：

  Selenium Regulates Expression in Rat Liver of Genes for Proteins Involved in Iron Metabolism

  摘要：

  Suppression subtractive hybridization analysis in our laboratory recently revealed that transferrin mRNA may be elevated in Se-deficient rat liver. In this work, we compared expression in rat liver of genes for transferrin, transferrin receptor, ferritin light and heavy chains, and iron-regulatory proteins 1 and 2 in Se adequacy and deficiency. Weanling male Sprague-Dawley rats were fed Torula yeast diets supplemented with 0 or 0.15 mu g Se/kg diet as sodium selenite for 15 wk. Activity of cellular glutathione peroxidase was virtually abolished in Se-deficient rat liver, whereas activity of glutathione S-transferase was 43% higher than in Se-adequate liver. There were no differences in hematocrit, hemoglobin, or liver iron content. To examine differential gene expression, we used a multiplex relative reverse transcriptase-polymerase chain reaction method. Three of the six genes examined showed modest but consistent upregulation in Se deficiency. Transferrin mRNA was 30% more abundant in Se-deficient than in Se-adequate liver. For the transferrin receptor, the difference was 32%, and for iron regulatory protein 1, it was 63%. No consistent differences were observed for iron regulatory protein 2 or for ferritin light or heavy chain. These findings suggest a possible role for dietary Se in moderating iron metabolism.

  DOI：

  10.1385/bter:74:1:55

文献信息

• General synthetic routes to β-hydroxy-acids from t-butyl esters and the Reformatskii reaction
  作者：D. A. Cornforth、A. E. Opara、G. Read

  DOI：10.1039/j39690002799

  日期：——

  modified Reformatskii procedure which leads directly to the hydroxy-acid. With highly hindered ketones or under conditions of inverse addition, self-condensation of the Reformatskii reagents from the t-butyl esters of α-bromopropionic acid and α-bromoisobutyric acid seriously reduce the yields of β-hydroxy-esters.

  通过（a）通过Reformatskii反应制得的叔丁基β-羟基酯的脱烷基化，以及（b）直接导致羟基的改进的Reformatskii方法，可以高收率合成各种各样的β-羟基酸。-酸。在高度受阻的酮中或在反加条件下，Reformatskii试剂从α-溴丙酸和α-溴异丁酸的叔丁基酯中的自缩合会严重降低β-羟基酯的收率。
• The Reformatsky Reaction. I. Condensation of Ketones and t-Butyl Bromoacetate by Magnesium
  作者：Tosio Moriwake

  DOI：10.1021/jo01341a524

  日期：1966.3
• Dubois,J.E. et al., Bulletin de la Societe Chimique de France, 1963, p. 1491 - 1496
  作者：Dubois,J.E. et al.

  DOI：——

  日期：——
• Dubois,J.-E.; Fellous,R., Bulletin de la Societe Chimique de France, 1963, p. 786 - 791
  作者：Dubois,J.-E.、Fellous,R.

  DOI：——

  日期：——
• Aldol Condensation of Esters with Ketones or Aldehydes to Form β-Hydroxy Esters by Lithium Amide. Comparison with the Reformatsky Reaction¹
  作者：Charles R. Hauser、W. H. Puterbaugh

  DOI：10.1021/ja01101a016

  日期：1953.3