(S)-3-((2S,3S,6R)-6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)butan-1-ol | 1044739-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: (S)-3-((2S,3S,6R)-6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)butan-1-ol
• CAS: 1044739-36-7
• 化学式: C₁₁H₂₀O₃
• 分子量: 200.278
• InChiKey: YZVCNHWDOUINRS-UKKRHICBSA-N

物化性质

• 沸点：
  288.2±40.0 °C(predicted)
• 密度：
  1.01±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  tert-butyl-[(S)-3-((2S,3S)-6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)butoxy]diphenylsilane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (S)-3-((2S,3S,6S)-6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)butan-1-ol 、 (S)-3-((2S,3S,6R)-6-methoxy-3-methyl-3,6-dihydro-2H-pyran-2-yl)butan-1-ol
  参考文献：
  名称：

  Synthetic studies toward cytostatin, a natural product inhibitor of protein phosphatase 2A

  摘要：

  Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy relying on the formation of the C8-C9 bond by a nucleophilic addition of a functionalized organolithium (C1-C8 subunit) to an aldehyde (C9-C13 subunit). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.012